Evaluation of Psoriasis Genetic Risk Based on Five Susceptibility Markers in a Population from Northern Poland
Publication Date
September 22, 2016
Journal
PLOS ONE
Authors
Marta Stawczyk Macieja, Krzysztof Rębała, Aneta Szczerkowska Dobosz, Joanna Wysocka, et al
Volume
11
Issue
9
Pages
e0163185
DOI
https://dx.plos.org/10.1371/journal.pone.0163185
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163185
Scopus
84992184222
Mendeley
http://www.mendeley.com/research/evaluation-psoriasis-genetic-risk-based-five-susceptibility-markers-population-northern-poland
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Mendeley | Further Information

{"title"=>"Evaluation of psoriasis genetic risk based on five susceptibility markers in a population from Northern Poland", "type"=>"journal", "authors"=>[{"first_name"=>"Marta", "last_name"=>"Stawczyk-Macieja", "scopus_author_id"=>"56081368800"}, {"first_name"=>"Krzysztof", "last_name"=>"Rȩbała", "scopus_author_id"=>"55885762300"}, {"first_name"=>"Aneta", "last_name"=>"Szczerkowska-Dobosz", "scopus_author_id"=>"6602659205"}, {"first_name"=>"Joanna", "last_name"=>"Wysocka", "scopus_author_id"=>"56973808600"}, {"first_name"=>"Lidia", "last_name"=>"Cybulska", "scopus_author_id"=>"22933430800"}, {"first_name"=>"Ewa", "last_name"=>"Kapińska", "scopus_author_id"=>"6507412191"}, {"first_name"=>"Agnieszka", "last_name"=>"Haraś", "scopus_author_id"=>"57191629558"}, {"first_name"=>"Paulina", "last_name"=>"Miniszewska", "scopus_author_id"=>"57191626254"}, {"first_name"=>"Roman", "last_name"=>"Nowicki", "scopus_author_id"=>"7004484706"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84992184222", "isbn"=>"1932-6203 (ISSNLinking)", "doi"=>"10.1371/journal.pone.0163185", "pui"=>"612774874", "sgr"=>"84992184222"}, "id"=>"64465b8e-6267-3288-be6f-c1d2505c0913", "abstract"=>"Psoriasis genetic background depends on polygenic and multifactorial mode of inheritance. As in other complex disorders, the estimation of the disease risk based on individual genetic variants is impossible. For this reason, recent investigations have been focused on combinations of known psoriasis susceptibility markers in order to improve the disease risk evaluation. Our aim was to compare psoriasis genetic risk score (GRS) for five susceptibility loci involved in the immunological response (HLA-C, ERAP1, ZAP70) and in the skin barrier function (LCE3, CSTA) between patients with chronic plaque psoriasis (n = 148) and the control group (n = 146). A significantly higher number of predisposing alleles was observed in patients with psoriasis in comparison to healthy individuals (6.1 vs. 5.2, respectively; P = 8.8×10-7). The statistical significance was even more profound when GRS weighted by logarithm odds ratios was evaluated (P = 9.9×10-14). Our results demonstrate the developed panel of five susceptibility loci to be more efficient in predicting psoriasis risk in the Polish population and to possess higher sensitivity and specificity for the disease than any of the markers analyzed separately, including the most informative HLA-C*06 allele.", "link"=>"http://www.mendeley.com/research/evaluation-psoriasis-genetic-risk-based-five-susceptibility-markers-population-northern-poland", "reader_count"=>4, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "group_count"=>0}

Scopus | Further Information

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