Novel IgG-Degrading Enzymes of the IgdE Protease Family Link Substrate Specificity to Host Tropism of Streptococcus Species
Publication Date
October 17, 2016
Journal
PLOS ONE
Authors
Christian Spoerry, Pontus Hessle, Melanie J. Lewis, Lois Paton, et al
Volume
11
Issue
10
Pages
e0164809
DOI
https://dx.plos.org/10.1371/journal.pone.0164809
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0164809
Web of Science
000386202300031
Scopus
84992426153
Mendeley
http://www.mendeley.com/research/novel-iggdegrading-enzymes-igde-protease-family-link-substrate-specificity-host-tropism-streptococcu
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Mendeley | Further Information

{"title"=>"Novel IgG-degrading enzymes of the IgdE protease family link substrate specificity to host tropism of streptococcus species", "type"=>"journal", "authors"=>[{"first_name"=>"Christian", "last_name"=>"Spoerry", "scopus_author_id"=>"55123266000"}, {"first_name"=>"Pontus", "last_name"=>"Hessle", "scopus_author_id"=>"57191646523"}, {"first_name"=>"Melanie J.", "last_name"=>"Lewis", "scopus_author_id"=>"9237548300"}, {"first_name"=>"Lois", "last_name"=>"Paton", "scopus_author_id"=>"57189749028"}, {"first_name"=>"Jenny M.", "last_name"=>"Woof", "scopus_author_id"=>"7003534192"}, {"first_name"=>"Ulrich", "last_name"=>"Von Pawel-Rammingen", "scopus_author_id"=>"6603056039"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84992426153", "issn"=>"19326203", "pui"=>"612829139", "sgr"=>"84992426153", "pmid"=>"27749921", "doi"=>"10.1371/journal.pone.0164809"}, "id"=>"8c566c64-63dc-320b-9645-dde9cfd5b659", "abstract"=>"Recently we have discovered an IgG degrading enzyme of the endemic pig pathogen S. suis designated IgdE that is highly specific for porcine IgG. This protease is the founding member of a novel cysteine protease family assigned C113 in the MEROPS peptidase database. Bioinformatical analyses revealed putative members of the IgdE protease family in eight other Streptococcus species. The genes of the putative IgdE family proteases of S. agalactiae, S. porcinus, S. pseudoporcinus and S. equi subsp. zooepidemicus were cloned for production of recombinant protein into expression vectors. Recombinant proteins of all four IgdE family proteases were proteolytically active against IgG of the respective Streptococcus species hosts, but not against IgG from other tested species or other classes of immunoglobulins, thereby linking the substrate specificity to the known host tropism. The novel IgdE family proteases of S. agalactiae, S. pseudoporcinus and S. equi showed IgG subtype specificity, i.e. IgdE from S. agalactiae and S. pseudoporcinus cleaved human IgG1, while IgdE from S. equi was subtype specific for equine IgG7. Porcine IgG subtype specificities of the IgdE family proteases of S. porcinus and S. pseudoporcinus remain to be determined. Cleavage of porcine IgG by IgdE of S. pseudoporcinus is suggested to be an evolutionary remaining activity reflecting ancestry of the human pathogen to the porcine pathogen S. porcinus. The IgG subtype specificity of bacterial proteases indicates the special importance of these IgG subtypes in counteracting infection or colonization and opportunistic streptococci neutralize such antibodies through expression of IgdE family proteases as putative immune evasion factors. We suggest that IgdE family proteases might be valid vaccine targets against streptococci of both human and veterinary medical concerns and could also be of therapeutic as well as biotechnological use.", "link"=>"http://www.mendeley.com/research/novel-iggdegrading-enzymes-igde-protease-family-link-substrate-specificity-host-tropism-streptococcu", "reader_count"=>8, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "group_count"=>0}

Scopus | Further Information

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