Chronic Opisthorchis viverrini Infection Changes the Liver Microbiome and Promotes Helicobacter Growth
Publication Date
November 02, 2016
Authors
Upsornsawan Itthitaetrakool, Porntip Pinlaor, Somchai Pinlaor, Chariya Chomvarin, et al
Volume
11
Issue
11
Pages
e0165798
DOI
https://dx.plos.org/10.1371/journal.pone.0165798
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165798
Scopus
84994635684
Mendeley
http://www.mendeley.com/research/chronic-opisthorchis-viverrini-infection-changes-liver-microbiome-promotes-helicobacter-growth
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Mendeley | Further Information

{"title"=>"Chronic opisthorchis viverrini infection changes the liver microbiome and promotes helicobacter growth", "type"=>"journal", "authors"=>[{"first_name"=>"Upsornsawan", "last_name"=>"Itthitaetrakool", "scopus_author_id"=>"57191906200"}, {"first_name"=>"Porntip", "last_name"=>"Pinlaor", "scopus_author_id"=>"6507689674"}, {"first_name"=>"Somchai", "last_name"=>"Pinlaor", "scopus_author_id"=>"6601920143"}, {"first_name"=>"Chariya", "last_name"=>"Chomvarin", "scopus_author_id"=>"6602223149"}, {"first_name"=>"Rungtiwa", "last_name"=>"Dangtakot", "scopus_author_id"=>"57191904060"}, {"first_name"=>"Apisit", "last_name"=>"Chaidee", "scopus_author_id"=>"56021963600"}, {"first_name"=>"Chotechana", "last_name"=>"Wilailuckana", "scopus_author_id"=>"14042673300"}, {"first_name"=>"Arunnee", "last_name"=>"Sangka", "scopus_author_id"=>"42262728600"}, {"first_name"=>"Aroonlug", "last_name"=>"Lulitanond", "scopus_author_id"=>"57188637390"}, {"first_name"=>"Puangrat", "last_name"=>"Yongvanit", "scopus_author_id"=>"6603446796"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84994635684", "pmid"=>"27806126", "scopus"=>"2-s2.0-84994635684", "pui"=>"612998566", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0165798"}, "id"=>"2b48fd4c-e80d-3b32-bf28-db63c3bc9946", "abstract"=>"Adults of Opisthorchis viverrini reside in the biliary system, inducing inflammation of bile ducts and cholangitis, leading to hepatobiliary disease (HBD) including cholangiocarcinoma. O. viverrini infection also has major implications for the bacterial community in bile ducts and liver. To investigate this in chronic O. viverrini infection (≥ 8 months p.i.), bacterial genomic DNA from livers of hamsters and from worms was investigated using culture techniques, PCR for Helicobacter spp. and high-throughput next-generation sequencing targeting the V3-V4 hypervariable regions of prokaryotic 16S rRNA gene. Of a total of 855,046 DNA sequence reads, 417,953 were useable after filtering. Metagenomic analyses assigned these to 93 operational taxonomic units (OTUs) consisting of 80 OTUs of bacteria, including 6 phyla and 42 genera. In the chronic O. viverrini-infected group, bacterial community composition and diversity were significantly increased compared to controls. Sequences of Fusobacterium spp. were the most common (13.81%), followed by Streptococcus luteciae (10.76%), Escherichia coli (10.18%), and Bifidobacterium spp. (0.58%). In addition, Helicobacter pylori (0.17% of sequences) was also identified in the liver of chronic O. viverrini infections, but not in normal liver. The presence of H. pylori was confirmed by PCR and by use of an antibody against bacterial antigen, supporting the metagenomics data. The identities of bacteria cultured for enrichment suggested that chronic O. viverrini infection changes the liver microbiome and promotes Helicobacter spp. growth. There may be synergy between O. viverrini and the liver microbiome in enhancing immune response-mediated hepatobiliary diseases.", "link"=>"http://www.mendeley.com/research/chronic-opisthorchis-viverrini-infection-changes-liver-microbiome-promotes-helicobacter-growth", "reader_count"=>13, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>2, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>2, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>3, "Veterinary Science and Veterinary Medicine"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>2, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Brazil"=>2, "Thailand"=>1}, "group_count"=>0}

Scopus | Further Information

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Net::HTTPTooManyRequests

Source
Scopus
Time
2019-09-27 10:09:34 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0165798)
Trace

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