Mendeley | Further Information

{"title"=>"The devil is in the details: Incomplete reporting in preclinical animal research", "type"=>"journal", "authors"=>[{"first_name"=>"Marc T.", "last_name"=>"Avey", "scopus_author_id"=>"23033413400"}, {"first_name"=>"David", "last_name"=>"Moher", "scopus_author_id"=>"7005443800"}, {"first_name"=>"Katrina J.", "last_name"=>"Sullivan", "scopus_author_id"=>"57052147200"}, {"first_name"=>"Dean", "last_name"=>"Fergusson", "scopus_author_id"=>"7102364909"}, {"first_name"=>"Gilly", "last_name"=>"Griffin", "scopus_author_id"=>"7201836470"}, {"first_name"=>"Jeremy M.", "last_name"=>"Grimshaw", "scopus_author_id"=>"34769948000"}, {"first_name"=>"Brian", "last_name"=>"Hutton", "scopus_author_id"=>"34570045800"}, {"first_name"=>"Manoj M.", "last_name"=>"Lalu", "scopus_author_id"=>"7801545674"}, {"first_name"=>"Malcolm", "last_name"=>"Macleod", "scopus_author_id"=>"7202645361"}, {"first_name"=>"John", "last_name"=>"Marshall", "scopus_author_id"=>"56485003100"}, {"first_name"=>"Shirley H.J.", "last_name"=>"Mei", "scopus_author_id"=>"14024682000"}, {"first_name"=>"Michael", "last_name"=>"Rudnicki", "scopus_author_id"=>"7102050259"}, {"first_name"=>"Duncan J.", "last_name"=>"Stewart", "scopus_author_id"=>"55613413700"}, {"first_name"=>"Alexis F.", "last_name"=>"Turgeon", "scopus_author_id"=>"7006753733"}, {"first_name"=>"Lauralyn", "last_name"=>"McIntyre", "scopus_author_id"=>"7101992439"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84995554768", "doi"=>"10.1371/journal.pone.0166733", "pmid"=>"27855228", "issn"=>"19326203", "scopus"=>"2-s2.0-84995554768", "pui"=>"613243957"}, "id"=>"4a2d77a6-28c8-31bc-b2f8-da342511c413", "abstract"=>"Incomplete reporting of study methods and results has become a focal point for failures in the reproducibility and translation of findings from preclinical research. Here we demonstrate that incomplete reporting of preclinical research is not limited to a few elements of research design, but rather is a broader problem that extends to the reporting of the methods and results. We evaluated 47 preclinical research studies from a systematic review of acute lung injury that use mesenchymal stem cells (MSCs) as a treatment. We operationalized the ARRIVE (Animal Research: Reporting of In Vivo Experiments) reporting guidelines for pre-clinical studies into 109 discrete reporting sub-items and extracted 5,123 data elements. Overall, studies reported less than half (47%) of all sub-items (median 51 items; range 37-64). Across all studies, the Methods Section reported less than half (45%) and the Results Section reported less than a third (29%). There was no association between journal impact factor and completeness of reporting, which suggests that incomplete reporting of preclinical research occurs across all journals regardless of their perceived prestige. Incomplete reporting of methods and results will impede attempts to replicate research findings and maximize the value of preclinical studies.", "link"=>"http://www.mendeley.com/research/devil-details-incomplete-reporting-preclinical-animal-research", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>7, "Student > Ph. D. Student"=>5, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>7, "Student > Ph. D. Student"=>5, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>7, "Neuroscience"=>3, "Veterinary Science and Veterinary Medicine"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>2}, "group_count"=>0}

CrossRef

• http://doi.org/10.1186/s41073-019-0069-3
• http://doi.org/10.1177/2398212818810689
• http://doi.org/10.1016/j.bcp.2017.04.008
• http://doi.org/10.1016/j.jneumeth.2017.11.019
• http://doi.org/10.1371/journal.pone.0215221
• http://doi.org/10.1093/toxsci/kfz128
• http://doi.org/10.1136/bmjos-2018-000016
• http://doi.org/10.3390/ani9110975
• http://doi.org/10.1177/0023677217724823
• http://doi.org/10.1016/j.nmd.2017.11.002
• http://doi.org/10.1371/journal.pbio.2006022
• http://doi.org/10.1093/ilar/ily020
• http://doi.org/10.1016/j.neubiorev.2018.12.023
• http://doi.org/10.1016/j.pnpbp.2020.109878
• http://doi.org/10.1161/HYP.0000000000000090
• http://doi.org/10.1016/j.omto.2019.05.004
• http://doi.org/10.1038/s41598-019-54152-8
• http://doi.org/10.1371/journal.pone.0197882
• http://doi.org/10.1136/bmjos-2018-000002

Scopus | Further Information

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• {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"17", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

F1000Prime