Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy
- Publication Date
- March 15, 2017
- Authors
- Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, et al
- Volume
- 12
- Issue
- 3
- Pages
- e0172995
- DOI
- https://dx.plos.org/10.1371/journal.pone.0172995
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0172995
- Scopus
- 85015292949
- Mendeley
- http://www.mendeley.com/research/exomewide-association-study-reveals-novel-susceptibility-genes-sporadic-dilated-cardiomyopathy
Loading … 

Events
Loading … 

Mendeley | Further Information
{"title"=>"Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy", "type"=>"journal", "authors"=>[{"first_name"=>"Ulrike", "last_name"=>"Esslinger", "scopus_author_id"=>"36628062500"}, {"first_name"=>"Sophie", "last_name"=>"Garnier", "scopus_author_id"=>"35847190200"}, {"first_name"=>"Agathe", "last_name"=>"Korniat", "scopus_author_id"=>"56862253600"}, {"first_name"=>"Carole", "last_name"=>"Proust", "scopus_author_id"=>"24462243900"}, {"first_name"=>"Georgios", "last_name"=>"Kararigas", "scopus_author_id"=>"36189316500"}, {"first_name"=>"Martina", "last_name"=>"Müller-Nurasyid", "scopus_author_id"=>"57195420172"}, {"first_name"=>"Jean Philippe", "last_name"=>"Empana", "scopus_author_id"=>"6601961797"}, {"first_name"=>"Michael P.", "last_name"=>"Morley", "scopus_author_id"=>"7006568349"}, {"first_name"=>"Claire", "last_name"=>"Perret", "scopus_author_id"=>"8708614600"}, {"first_name"=>"Klaus", "last_name"=>"Stark", "scopus_author_id"=>"55196381400"}, {"first_name"=>"Alexander G.", "last_name"=>"Bick", "scopus_author_id"=>"55979721500"}, {"first_name"=>"Sanjay K.", "last_name"=>"Prasad", "scopus_author_id"=>"7403003613"}, {"first_name"=>"Jennifer", "last_name"=>"Kriebel", "scopus_author_id"=>"56458355400"}, {"first_name"=>"Jin", "last_name"=>"Li", "scopus_author_id"=>"55894805800"}, {"first_name"=>"Laurence", "last_name"=>"Tiret", "scopus_author_id"=>"7006257206"}, {"first_name"=>"Konstantin", "last_name"=>"Strauch", "scopus_author_id"=>"57021167300"}, {"first_name"=>"Declan P.", "last_name"=>"O'Regan", "scopus_author_id"=>"8874856800"}, {"first_name"=>"Kenneth B.", "last_name"=>"Marguiles", "scopus_author_id"=>"57193627487"}, {"first_name"=>"Jonathan G.", "last_name"=>"Seidman", "scopus_author_id"=>"7101816720"}, {"first_name"=>"Pierre", "last_name"=>"Boutouyrie", "scopus_author_id"=>"7006629612"}, {"first_name"=>"Patrick", "last_name"=>"Lacolley", "scopus_author_id"=>"7004924709"}, {"first_name"=>"Xavier", "last_name"=>"Jouven", "scopus_author_id"=>"7003891080"}, {"first_name"=>"Christian", "last_name"=>"Hengstenberg", "scopus_author_id"=>"7003528759"}, {"first_name"=>"Michel", "last_name"=>"Komajda", "scopus_author_id"=>"7102980352"}, {"first_name"=>"Hakon", "last_name"=>"Hakonarson", "scopus_author_id"=>"55531171800"}, {"first_name"=>"Richard", "last_name"=>"Isnard", "scopus_author_id"=>"56214031100"}, {"first_name"=>"Eloisa", "last_name"=>"Arbustini", "scopus_author_id"=>"7006508645"}, {"first_name"=>"Harald", "last_name"=>"Grallert", "scopus_author_id"=>"16067125800"}, {"first_name"=>"Stuart A.", "last_name"=>"Cook", "scopus_author_id"=>"7402119166"}, {"first_name"=>"Christine E.", "last_name"=>"Seidman", "scopus_author_id"=>"7101936253"}, {"first_name"=>"Vera", "last_name"=>"Regitz-Zagrosek", "scopus_author_id"=>"7006921582"}, {"first_name"=>"Thomas P.", "last_name"=>"Cappola", "scopus_author_id"=>"57191818330"}, {"first_name"=>"Philippe", "last_name"=>"Charron", "scopus_author_id"=>"57189240205"}, {"first_name"=>"François", "last_name"=>"Cambien", "scopus_author_id"=>"7101622418"}, {"first_name"=>"Eric", "last_name"=>"Villard", "scopus_author_id"=>"6602181960"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85015292949", "pui"=>"614792239", "doi"=>"10.1371/journal.pone.0172995", "isbn"=>"1111111111", "sgr"=>"85015292949", "pmid"=>"28296976"}, "id"=>"3fe7f42a-ba84-34dc-8e55-81bc55220d10", "abstract"=>"AIMS Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM. METHODS AND RESULTS 116,855 single nucleotide variants (SNVs) were analyzed in 2796 DCM patients and 6877 control subjects from 6 populations of European ancestry. We confirmed two previously identified associations with SNVs in BAG3 and ZBTB17 and discovered six novel DCM-associated loci (Q-value<0.01). The lead-SNVs at novel loci are common and located in TTN, SLC39A8, MLIP, FLNC, ALPK3 and FHOD3. In silico fine mapping identified HSPB7 as the most likely candidate at the ZBTB17 locus. Rare variant analysis (MAF<0.01) demonstrated significant association for TTN variants only (P = 0.0085). All candidate genes but one (SLC39A8) exhibit preferential expression in striated muscle tissues and mutations in TTN, BAG3, FLNC and FHOD3 are known to cause familial cardiomyopathy. We also investigated a panel of 48 known cardiomyopathy genes. Collectively, rare (n = 228, P = 0.0033) or common (n = 36, P = 0.019) variants with elevated in silico severity scores were associated with DCM, indicating that the spectrum of genes contributing to sporadic DCM extends beyond those identified here. CONCLUSION We identified eight loci independently associated with sporadic DCM. The functions of the best candidate genes at these loci suggest that proteostasis regulation might play a role in DCM pathophysiology.", "link"=>"http://www.mendeley.com/research/exomewide-association-study-reveals-novel-susceptibility-genes-sporadic-dilated-cardiomyopathy", "reader_count"=>30, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>8, "Mathematics"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>0}CrossRef
- http://doi.org/10.1007/s11936-019-0742-3
- http://doi.org/10.1186/s40246-019-0233-3
- http://doi.org/10.1111/jcmm.14607
- http://doi.org/10.1016/j.jacc.2018.09.026
- http://doi.org/10.1074/jbc.RA118.003758
- http://doi.org/10.1093/cvr/cvy083
- http://doi.org/10.1016/j.jacc.2018.10.001
- http://doi.org/10.1074/jbc.M117.800888
- http://doi.org/10.1007/s00380-017-1110-4
- http://doi.org/10.1042/BSR20180934
- http://doi.org/10.1161/CIRCULATIONAHA.118.035774
- http://doi.org/10.1016/j.ejmg.2018.09.007
- http://doi.org/10.1016/j.jacbts.2017.07.010
- http://doi.org/10.1161/CIRCULATIONAHA.118.035954
- http://doi.org/10.1146/annurev-biodatasci-080917-013508
- http://doi.org/10.1515/cclm-2017-0461
- http://doi.org/10.1016/j.jacbts.2017.09.009
- http://doi.org/10.1001/jamacardio.2018.2541
Scopus | Further Information
{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85015292949"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85015292949?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85015292949&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85015292949&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85015292949", "dc:identifier"=>"SCOPUS_ID:85015292949", "eid"=>"2-s2.0-85015292949", "dc:title"=>"Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy", "dc:creator"=>"Esslinger U.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-03-01", "prism:coverDisplayDate"=>"March 2017", "prism:doi"=>"10.1371/journal.pone.0172995", "citedby-count"=>"16", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Inserm", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}, {"@_fa"=>"true", "affilname"=>"ICAN Institute for Cardiometabolism and Nutrition", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}], "pubmed-id"=>"28296976", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0172995", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}- {"id"=>"842417933447962624", "text"=>"Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. https://t.co/oa6K7D0wFe", "created_at"=>"2017-03-16T16:51:01Z", "user"=>"PLOSONE", "user_name"=>"PLOS ONE", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2429958559/mzjl6as5u2m09r2erof6_normal.jpeg"}
- {"id"=>"844105402820235264", "text"=>"Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy https://t.co/XutSLC0Xs9", "created_at"=>"2017-03-21T08:36:25Z", "user"=>"kanteron", "user_name"=>"Kanteron Systems", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1211638233/KdeKanteron_normal.png"}
- {"id"=>"844106194751045632", "text"=>"https://t.co/UuF0m1FEWs https://t.co/UuF0m1FEWs", "created_at"=>"2017-03-21T08:39:34Z", "user"=>"jorgecortell", "user_name"=>"Jorge Cortell", "user_profile_image"=>"http://pbs.twimg.com/profile_images/757599936791838720/L4nhD7mp_normal.jpg"}
- {"id"=>"846348089900388354", "text"=>"RT @PLOSONE: Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. https://t.co/oa6K7D0wFe", "created_at"=>"2017-03-27T13:08:03Z", "user"=>"MPAlonso", "user_name"=>"Manuel P?rez-Alonso", "user_profile_image"=>"http://pbs.twimg.com/profile_images/802875675652882433/EZnuLfDM_normal.jpg"}
Counter
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"140", "xml_views"=>"6", "html_views"=>"616"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"75", "xml_views"=>"1", "html_views"=>"280"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"286"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"109"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"92"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"3", "html_views"=>"74"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"3", "html_views"=>"71"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"94"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"209"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"321"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"45"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"40"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"39"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"15"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"4", "html_views"=>"39"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"48"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"43"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"40"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"31"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"22"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"42"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"37"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"24"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"26"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"4", "html_views"=>"35"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"25"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"36"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"24"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"10"}
PMC Usage Stats
- {"unique-ip"=>"46", "full-text"=>"86", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"52", "full-text"=>"75", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"39", "full-text"=>"45", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"31", "full-text"=>"38", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"44", "full-text"=>"42", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"54", "full-text"=>"52", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"26", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"42", "full-text"=>"44", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"22", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"32", "full-text"=>"31", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"30", "full-text"=>"38", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
- {"unique-ip"=>"39", "full-text"=>"42", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"23", "full-text"=>"34", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"31", "full-text"=>"32", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"33", "full-text"=>"31", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"34", "full-text"=>"28", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"43", "full-text"=>"52", "pdf"=>"21", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"29", "full-text"=>"41", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"24", "full-text"=>"29", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"28", "full-text"=>"41", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"19", "full-text"=>"28", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"23", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"22", "full-text"=>"38", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
- {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
- {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
Loading … 

There are currently no alerts