Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells
Publication Date
April 27, 2017
Authors
Mohammad Alimohammadi, Mohamed Hassen Lahiani, Diamond Mc Gehee & Mariya Khodakovskaya
Volume
12
Issue
4
Pages
e0175778
DOI
https://dx.plos.org/10.1371/journal.pone.0175778
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0175778
Scopus
85018281719
Mendeley
http://www.mendeley.com/research/polyphenolic-extract-insp-5ptase-expressing-tomato-plants-reduce-proliferation-mcf7-breast-cancer-ce
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Mendeley | Further Information

{"title"=>"Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells", "type"=>"journal", "authors"=>[{"first_name"=>"Mohammad", "last_name"=>"Alimohammadi", "scopus_author_id"=>"35267831100"}, {"first_name"=>"Mohamed Hassen", "last_name"=>"Lahiani", "scopus_author_id"=>"35253997800"}, {"first_name"=>"Diamond", "last_name"=>"McGehee", "scopus_author_id"=>"57194018398"}, {"first_name"=>"Mariya", "last_name"=>"Khodakovskaya", "scopus_author_id"=>"8643040800"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85018281719", "pmid"=>"28448505", "pui"=>"615714799", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85018281719", "doi"=>"10.1371/journal.pone.0175778", "issn"=>"19326203"}, "id"=>"24b85bd6-2498-3a79-a188-e79373803cc0", "abstract"=>"In recent years, by extensive achievements in understanding the mechanisms and the pathways affected by cancer, the focus of cancer research is shifting from developing new chemotherapy methods to using natural compounds with therapeutic properties to reduce the adverse effects of synthetic drugs on human health. We used fruit extracts from previously generated human type I InsP 5-ptase gene expressing transgenic tomato plants for assessment of the anti-cancer activity of established genetically modified tomato lines. Cellular assays (MTT, Fluorescent microscopy, Flow Cytometry analysis) were used to confirm that InsP 5-ptase fruit extract was more effective for reducing the proliferation of breast cancer cells compared to wild-type tomato fruit extract. Metabolome analysis of InsP 5-ptase expressing tomato fruits performed by LC-MS identified tomato metabolites that may play a key role in the increased anti-cancer activity observed for the transgenic fruits. Total transcriptome analysis of cancer cells (MCF-7 line) exposed to an extract of transgenic fruits revealed a number of differently regulated genes in the cells treated with transgenic extract compared to untreated cells or cells treated with wild-type tomato extract. Together, this data demonstrate the potential role of the plant derived metabolites in suppressing cell viability of cancer cells and further prove the potential application of plant genetic engineering in the cancer research and drug discovery.", "link"=>"http://www.mendeley.com/research/polyphenolic-extract-insp-5ptase-expressing-tomato-plants-reduce-proliferation-mcf7-breast-cancer-ce", "reader_count"=>11, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Other"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Other"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>3}

Scopus | Further Information

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