Mendeley | Further Information

{"title"=>"HIV transmitted/founder vaccines elicit autologous tier 2 neutralizing antibodies for the CD4 binding site", "type"=>"journal", "authors"=>[{"first_name"=>"Nathanael P.", "last_name"=>"McCurley", "scopus_author_id"=>"36548703800"}, {"first_name"=>"Arban", "last_name"=>"Domi", "scopus_author_id"=>"6507984167"}, {"first_name"=>"Rahul", "last_name"=>"Basu", "scopus_author_id"=>"56392532500"}, {"first_name"=>"Kevin O.", "last_name"=>"Saunders", "scopus_author_id"=>"26640762900"}, {"first_name"=>"Celia C.", "last_name"=>"LaBranche", "scopus_author_id"=>"6602355898"}, {"first_name"=>"David C.", "last_name"=>"Montefiori", "scopus_author_id"=>"7005651585"}, {"first_name"=>"Barton F.", "last_name"=>"Haynes", "scopus_author_id"=>"26430746300"}, {"first_name"=>"Harriet L.", "last_name"=>"Robinson", "scopus_author_id"=>"7202477918"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"618698333", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0177863", "scopus"=>"2-s2.0-85031296331", "isbn"=>"1111111111", "sgr"=>"85031296331"}, "id"=>"5b9c6365-5573-37f2-bdea-035983513704", "abstract"=>"Here we report the construction, antigenicity and initial immunogenicity testing of DNA and modified vaccinia Ankara (MVA) vaccines expressing virus-like particles (VLPs) displaying sequential clade C Envelopes (Envs) that co-evolved with the elicitation of broadly neutralizing antibodies (bnAbs) to the CD4 binding site (CD4bs) in HIV-infected individual CH0505. The VLP-displayed Envs showed reactivity for conformational epitopes displayed on the receptor-binding form of Env. Two inoculations of the DNA-T/F vaccine, followed by 3 inoculations of the MVA-T/F vaccine and a final inoculation of the MVA-T/F plus a gp120-T/F protein vaccine elicited nAb to the T/F virus in 2 of 4 rhesus macaques (ID50 of ~175 and ~30). Neutralizing Ab plateaued at 100% neutralization and mapped to the CD4bs like the bnAbs elicited in CH0505. The nAb did not have breadth for other tier 2 viruses. Immunizations with T/F followed by directed-lineage vaccines, both with and without co-delivery of directed-lineage gp120 boosts, failed to elicit tier 2 neutralizing Ab for the CD4bs. Thus, pulsed exposures to DNA and MVA-expressed VLPs plus gp120 protein of a T/F Env can induce autologous tier 2 nAbs to the CD4bs.", "link"=>"http://www.mendeley.com/research/hiv-transmittedfounder-vaccines-elicit-autologous-tier-2-neutralizing-antibodies-cd4-binding-site", "reader_count"=>4, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

CrossRef

• http://doi.org/10.3390/pathogens8030133
• http://doi.org/10.3389/fimmu.2018.00345
• http://doi.org/10.1186/s12977-018-0457-7
• http://doi.org/10.3390/v10040167
• http://doi.org/10.1002/cpt.1208

Scopus | Further Information

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• {"id"=>"918177013923381248", "text"=>"MC of 2.4m, novel Zika vaccine, and this HIV serology in primates.... $GOVX https://t.co/L7fZNCINnZ", "created_at"=>"2017-10-11T18:10:33Z", "user"=>"spontonic", "user_name"=>"Spontonic", "user_profile_image"=>"http://pbs.twimg.com/profile_images/643595645593358336/Jx-GMPKn_normal.jpg"}
• {"id"=>"918193402843402242", "text"=>"#PLOSONE: HIV vaccine from GeoVax elicits autologous tier 2 neutralizing antibodies ... https://t.co/U4wq0DDe9p", "created_at"=>"2017-10-11T19:15:41Z", "user"=>"biophile6", "user_name"=>"biophile6", "user_profile_image"=>"http://pbs.twimg.com/profile_images/595340654424633344/p6K9aECh_normal.jpg"}
• {"id"=>"918478571131240449", "text"=>"#HIV transmitted/founder vaccines elicit autologous tier 2 neutralizing antibodies for the CD4 binding site https://t.co/p25GAHmHxE @PLOSONE", "created_at"=>"2017-10-12T14:08:50Z", "user"=>"TAGHIVscience", "user_name"=>"TAGHIVscience", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000408365735/6faf498418bf2dc907cbb5eb08461603_normal.png"}
• {"id"=>"923921856419295232", "text"=>"Geovax Labs, Inc. symbol $GOVX trading at $0.05 is on brink of a Medical Breakthrough with a cure for HIV\n\nhttps://t.co/qdXGdWogzt", "created_at"=>"2017-10-27T14:38:30Z", "user"=>"RCat55", "user_name"=>"RC-55", "user_profile_image"=>"http://pbs.twimg.com/profile_images/907412021515354113/z9hXPgxL_normal.jpg"}

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