Interleukin-10/lymphocyte ratio predicts mortality in severe septic patients
Publication Date
June 19, 2017
Authors
Xi Li, Zhiheng Xu, Xiaoqing Pang, Yongbo Huang, et al
Volume
12
Issue
6
Pages
e0179050
DOI
https://dx.plos.org/10.1371/journal.pone.0179050
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0179050
Scopus
85020939218
Mendeley
http://www.mendeley.com/research/interleukin10lymphocyte-ratio-predicts-mortality-severe-septic-patients-1
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Mendeley | Further Information

{"title"=>"Interleukin-10/lymphocyte ratio predicts mortality in severe septic patients", "type"=>"journal", "authors"=>[{"first_name"=>"Xi", "last_name"=>"Li", "scopus_author_id"=>"57196399554"}, {"first_name"=>"Zhiheng", "last_name"=>"Xu", "scopus_author_id"=>"56962907400"}, {"first_name"=>"Xiaoqing", "last_name"=>"Pang", "scopus_author_id"=>"56263243700"}, {"first_name"=>"Yongbo", "last_name"=>"Huang", "scopus_author_id"=>"53463605500"}, {"first_name"=>"Baoxin", "last_name"=>"Yang", "scopus_author_id"=>"57191278514"}, {"first_name"=>"Yuanyuan", "last_name"=>"Yang", "scopus_author_id"=>"57191275866"}, {"first_name"=>"Kangxie", "last_name"=>"Chen", "scopus_author_id"=>"57191287199"}, {"first_name"=>"Xiaoqing", "last_name"=>"Liu", "scopus_author_id"=>"56369743100"}, {"first_name"=>"Pu", "last_name"=>"Mao", "scopus_author_id"=>"47361201300"}, {"first_name"=>"Yimin", "last_name"=>"Li", "scopus_author_id"=>"55925657400"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85020939218", "doi"=>"10.1371/journal.pone.0179050", "scopus"=>"2-s2.0-85020939218", "pui"=>"616845656", "isbn"=>"1111111111", "issn"=>"19326203"}, "id"=>"00cddb1b-546c-3238-bd34-4aabf81a5966", "abstract"=>"Background: Immunosuppression is common even in the early stage of severe sepsis. Interleukin-10 (IL- 10) secretion and lymphocyte exhaustion are the main features of sepsis-induced immuno- suppression. However, the relationship between IL-10 and the lymphocyte is still unclear. Weinvestigated if IL-10/lymphocyte ratio (IL10LCR) were associated with mortality in severe septic patients. Methods: Adult patients with severe sepsis admitted to ICU of the First Affiliated Hospital of Guang- zhou Medical University were identified from October 2012 to August 2013. Within 24 hours of ICU admission, peripheral whole blood was collected for the measurement of IL-10 using commercial multiplex bead-based assay kits and determination of lymphocyte count from laboratory data. The primary outcome was 28-day mortality. Results: Atotal of 63 severe sepsis patients were identified. There were 20 (32%) patients died within 28 days. IL10LCR in non-survival patients was significantly higher than survival patients (median (IQR) 36.78 (12.34–79.63) ng/ml2 versus 11.01(5.41–27.50) ng/ml2, P= 0.002). Correlation analysis showed that IL10LCR was significantly correlated with APACHE II score (Spearman’s rho = 0.424, P<0.001). The receiver operating characteristic (ROC) curves showed the area under the curve was 0.749 for IL10LCR level to predict 28-day mortality with sensitivity and specificity at 70.0% and 74.4%, respectively. At an optimal cutoff of 23.39ng/ml2, Kaplan-Meier curve showed survival in patients with IL10LCR level above 23.39ng/ml2 was significantly lower than in patients with IL10LCR level less than 23.39ng/ml2 (P= 0.001 by log-rank test). Conclusion: IL10LCR level is significantly associated with the severity and outcome of severe septic patients. It may serve as a biomarker for sepsis-induced immunosuppression.", "link"=>"http://www.mendeley.com/research/interleukin10lymphocyte-ratio-predicts-mortality-severe-septic-patients-1", "reader_count"=>5, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Business, Management and Accounting"=>2}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

Scopus | Further Information

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