Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function
Publication Date
September 21, 2017
Authors
Ana Ortega, Estefanía Tarazón, Carolina Gil Cayuela, María García Manzanares, et al
Volume
12
Issue
9
Pages
e0185062
DOI
https://dx.plos.org/10.1371/journal.pone.0185062
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185062
Scopus
85029765184
Mendeley
http://www.mendeley.com/research/intercalated-disc-failing-hearts-patients-dilated-cardiomyopathy-role-depressed-left-ventricular-fun
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function", "type"=>"journal", "authors"=>[{"first_name"=>"Ana", "last_name"=>"Ortega", "scopus_author_id"=>"57197446763"}, {"first_name"=>"Estefanía", "last_name"=>"Tarazón", "scopus_author_id"=>"55279833300"}, {"first_name"=>"Carolina", "last_name"=>"Gil-Cayuela", "scopus_author_id"=>"56566607100"}, {"first_name"=>"María", "last_name"=>"García-Manzanares", "scopus_author_id"=>"57195339347"}, {"first_name"=>"Luis", "last_name"=>"Martínez-Dolz", "scopus_author_id"=>"6701541186"}, {"first_name"=>"Francisca", "last_name"=>"Lago", "scopus_author_id"=>"6603957369"}, {"first_name"=>"José Ramón", "last_name"=>"González-Juanatey", "scopus_author_id"=>"7005529659"}, {"first_name"=>"Juan", "last_name"=>"Cinca", "scopus_author_id"=>"57188663506"}, {"first_name"=>"Esther", "last_name"=>"Jorge", "scopus_author_id"=>"36504209400"}, {"first_name"=>"Manuel", "last_name"=>"Portolés", "scopus_author_id"=>"56910660100"}, {"first_name"=>"Esther", "last_name"=>"Roselló-Lletí", "scopus_author_id"=>"15829906300"}, {"first_name"=>"Miguel", "last_name"=>"Rivera", "scopus_author_id"=>"8948887200"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85029765184", "sgr"=>"85029765184", "pui"=>"618383630", "isbn"=>"1111111111", "pmid"=>"28934278", "doi"=>"10.1371/journal.pone.0185062"}, "id"=>"495068a9-ae7a-3e7b-82d0-5c973c72eade", "abstract"=>"Alterations in myocardial structure and reduced cardiomyocyte adhesions have been previously described in dilated cardiomyopathy (DCM). We studied the transcriptome of cell adhesion molecules in these patients and their relationships with left ventricular (LV) function decay. We also visualized the intercalated disc (ID) structure and organization. The transcriptomic profile of 23 explanted LV samples was analyzed using RNA-sequencing (13 DCM, 10 control [CNT]), focusing on cell adhesion genes. Electron microscopy analysis to visualize ID structural differences and immunohistochemistry experiments of ID proteins was also performed. RT-qPCR and western blot experiments were carried out on ID components. We found 29 differentially expressed genes, most of all, constituents of the ID structure. We found that the expression of GJA3, DSP and CTNNA3 was directly associated with LV ejection fraction (r = 0.741, P = 0.004; r = 0.674, P = 0.011 and r = 0.565, P = 0.044, respectively), LV systolic (P = 0.003, P = 0.003, P = 0.028, respectively) and diastolic dimensions (P = 0.006, P = 0.001, P = 0.025, respectively). Electron microscopy micrographs showed a reduced ID convolution index and immunogold labeling of connexin 46 (GJA gene), desmoplakin (DSP gene) and catenin alpha-3 (CTNNA3 gene) proteins in DCM patients. Moreover, we observed that protein and mRNA levels analyzed by RT-qPCR of these ID components were diminished in DCM group. In conclusion, we report significant gene and protein expression changes and found that the ID components GJA3, DSP and CTNNA3 were highly related to LV function. Microscopic observations indicated that ID is structurally compromised in these patients. These findings give new data for understanding the ventricular depression that characterizes DCM, opening new therapeutic perspectives for these critically diseased patients.", "link"=>"http://www.mendeley.com/research/intercalated-disc-failing-hearts-patients-dilated-cardiomyopathy-role-depressed-left-ventricular-fun", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>4, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85029765184"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85029765184?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029765184&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85029765184&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85029765184", "dc:identifier"=>"SCOPUS_ID:85029765184", "eid"=>"2-s2.0-85029765184", "dc:title"=>"Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function", "dc:creator"=>"Ortega A.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-09-01", "prism:coverDisplayDate"=>"September 2017", "prism:doi"=>"10.1371/journal.pone.0185062", "citedby-count"=>"2", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Center for Biomedical Research Network in Cardiovascular Diseases (CIBERCV)", "affiliation-city"=>"Madrid", "affiliation-country"=>"Spain"}, {"@_fa"=>"true", "affilname"=>"Health Research Institute La Fe", "affiliation-city"=>"Valencia", "affiliation-country"=>"Spain"}], "pubmed-id"=>"28934278", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0185062", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"67", "xml_views"=>"9", "html_views"=>"150"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"158"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"248"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}

PMC Usage Stats

  • {"unique-ip"=>"25", "full-text"=>"23", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"35", "full-text"=>"52", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
Loading … Spinner
There are currently no alerts