Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
Publication Date
October 10, 2017
Authors
Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, et al
Volume
12
Issue
10
Pages
e0186021
DOI
https://dx.plos.org/10.1371/journal.pone.0186021
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0186021
Scopus
85030999915
Mendeley
http://www.mendeley.com/research/small-heterodimer-partner-shp-deficiency-protects-myocardia-lipid-accumulation-high-fat-dietfed-mice
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Mendeley | Further Information

{"title"=>"Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice", "type"=>"journal", "authors"=>[{"first_name"=>"Jung Hun", "last_name"=>"Ohn", "scopus_author_id"=>"8647162700"}, {"first_name"=>"Ji Yeon", "last_name"=>"Hwang", "scopus_author_id"=>"55915174200"}, {"first_name"=>"Min Kyong", "last_name"=>"Moon", "scopus_author_id"=>"36123604500"}, {"first_name"=>"Hwa Young", "last_name"=>"Ahn", "scopus_author_id"=>"35114456100"}, {"first_name"=>"Hwan Hee", "last_name"=>"Kim", "scopus_author_id"=>"37066229400"}, {"first_name"=>"Young Do", "last_name"=>"Koo", "scopus_author_id"=>"55361434700"}, {"first_name"=>"Kwang Il", "last_name"=>"Kim", "scopus_author_id"=>"57193847032"}, {"first_name"=>"Hyuk Jae", "last_name"=>"Chang", "scopus_author_id"=>"8893464800"}, {"first_name"=>"Hye Seung", "last_name"=>"Lee", "scopus_author_id"=>"57102095800"}, {"first_name"=>"Hak Chul", "last_name"=>"Jang", "scopus_author_id"=>"57020615900"}, {"first_name"=>"Young Joo", "last_name"=>"Park", "scopus_author_id"=>"57200130664"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0186021", "sgr"=>"85030999915", "scopus"=>"2-s2.0-85030999915", "isbn"=>"1111111111", "pui"=>"618693457"}, "id"=>"82c2262f-a1f2-33f2-a6dc-aa682a2ba484", "abstract"=>"© 2017 Ohn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The small heterodimer partner (SHP) regulates fatty acid oxidation and lipogenesis in the liver by regulating peroxisome proliferator-activated receptor (PPAR) γ expression. SHP is also abundantly expressed in the myocardium. We investigated the effect of SHP expression on myocardia assessing not only heart structure and function but also lipid metabolism and related gene expression in a SHP deletion animal model. Transcriptional profiling with a microarray revealed that genes participating in cell growth, cytokine signalling, phospholipid metabolism, and extracellular matrix are up-regulated in the myocardia of SHP knockout (KO) mice compared to those of wild-type (WT) mice (nominal p value < 0.05). Consistent with these gene expression changes, the left ventricular masses of SHP KO mice were significantly higher than WT mice (76.8 ± 20.5 mg vs. 52.8 ± 6.8 mg, P = 0.0093). After 12 weeks of high fat diet (HFD), SHP KO mice gained less weight and exhibited less elevation in serum-free fatty acid and less ectopic lipid accumulation in the myocardium than WT mice. According to microarray analysis, genes regulated by PPARγ1 and PPARα were down-regulated in myocardia of SHP KO mice compared to their expression in WT mice after HFD, suggesting that the reduction in lipid accumulation in the myocardium resulted from a decrease in lipogenesis regulated by PPARγ. We confirmed the reduced expression of PPARγ1 and PPARα target genes such as CD36, medium-chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, and very long-chain acyl-CoA dehydrogenase by SHP KO after HFD.", "link"=>"http://www.mendeley.com/research/small-heterodimer-partner-shp-deficiency-protects-myocardia-lipid-accumulation-high-fat-dietfed-mice", "reader_count"=>3, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Other"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Other"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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