Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults
Publication Date
April 12, 2018
Authors
Prabha Siddarth, Alison C. Burggren, Harris A. Eyre, Gary W. Small, et al
Volume
13
Issue
4
Pages
e0195549
DOI
https://dx.plos.org/10.1371/journal.pone.0195549
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0195549
Scopus
85045477575
Mendeley
http://www.mendeley.com/research/sedentary-behavior-associated-reduced-medial-temporal-lobe-thickness-middleaged-older-adults
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults", "type"=>"journal", "authors"=>[{"first_name"=>"Prabha", "last_name"=>"Siddarth"}, {"first_name"=>"Alison C.", "last_name"=>"Burggren"}, {"first_name"=>"Harris A.", "last_name"=>"Eyre"}, {"first_name"=>"Gary W.", "last_name"=>"Small"}, {"first_name"=>"David A.", "last_name"=>"Merrill"}], "year"=>2018, "source"=>"PLOS ONE", "identifiers"=>{"sgr"=>"85045477575", "pui"=>"621640015", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85045477575", "doi"=>"10.1371/journal.pone.0195549", "issn"=>"1932-6203"}, "id"=>"9aefc0e6-814c-3f4a-bdb2-6044323de72f", "abstract"=>"Atrophy of the medial temporal lobe (MTL) occurs with aging, resulting in impaired episodic memory. Aerobic fitness is positively correlated with total hippocampal volume, a heavily studied memory-critical region within the MTL. However, research on associations between sedentary behavior and MTL subregion integrity is limited. Here we explore associations between thickness of the MTL and its subregions (namely CA1, CA23DG, fusiform gyrus, subiculum, parahippocampal, perirhinal and entorhinal cortex,), physical activity, and sedentary behavior. We assessed 35 non-demented middle-aged and older adults (25 women, 10 men; 45–75 years) using the International Physical Activity Questionnaire for older adults, which quantifies physical activity levels in MET-equivalent units and asks about the average number of hours spent sitting per day. All participants had high resolution MRI scans performed on a Siemens Allegra 3T MRI scanner, which allows for detailed investigation of the MTL. Controlling for age, total MTL thickness correlated inversely with hours of sitting/day (r = -0.37, p = 0.03). In MTL subregion analysis, parahippocampal (r = -0.45, p = 0.007), entorhinal (r = -0.33, p = 0.05) cortical and subiculum (r = -0.36, p = .04) thicknesses correlated inversely with hours of sitting/day. No significant correlations were observed between physical activity levels and MTL thickness. Though preliminary, our results suggest that more sedentary non-demented individuals have less MTL thickness. Future studies should include longitudinal analyses and explore mechanisms, as well as the efficacy of decreasing sedentary behaviors to reverse this association.", "link"=>"http://www.mendeley.com/research/sedentary-behavior-associated-reduced-medial-temporal-lobe-thickness-middleaged-older-adults", "reader_count"=>20, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Other"=>3, "Professor"=>2, "Unspecified"=>2, "Student > Bachelor"=>1, "Student > Postgraduate"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Other"=>3, "Professor"=>2, "Unspecified"=>2, "Student > Bachelor"=>1, "Student > Postgraduate"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>4, "Psychology"=>3, "Unspecified"=>4, "Agricultural and Biological Sciences"=>1, "Energy"=>1, "Immunology and Microbiology"=>1, "Neuroscience"=>2, "Environmental Science"=>1, "Arts and Humanities"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>2}, "Energy"=>{"Energy"=>1}, "Psychology"=>{"Psychology"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85045477575"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85045477575?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045477575&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85045477575&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85045477575", "dc:identifier"=>"SCOPUS_ID:85045477575", "eid"=>"2-s2.0-85045477575", "dc:title"=>"Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults", "dc:creator"=>"Siddarth P.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"13", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2018-04-01", "prism:coverDisplayDate"=>"April 2018", "prism:doi"=>"10.1371/journal.pone.0195549", "citedby-count"=>"11", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Jane & Terry Semel Institute for Neuroscience & Human Behavior", "affiliation-city"=>"Los Angeles", "affiliation-country"=>"United States"}], "pubmed-id"=>"29649304", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0195549", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Twitter

Counter

  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2298", "xml_views"=>"59", "html_views"=>"17054"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"1051", "xml_views"=>"28", "html_views"=>"3283"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"168", "xml_views"=>"15", "html_views"=>"851"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"71", "xml_views"=>"3", "html_views"=>"524"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"72", "xml_views"=>"2", "html_views"=>"412"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"104", "xml_views"=>"2", "html_views"=>"528"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"69", "xml_views"=>"1", "html_views"=>"533"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"75", "xml_views"=>"1", "html_views"=>"347"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"49", "xml_views"=>"2", "html_views"=>"298"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"243"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"183"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"211"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"221"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"54", "xml_views"=>"3", "html_views"=>"213"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"53", "xml_views"=>"1", "html_views"=>"170"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"3", "html_views"=>"1151"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"36", "xml_views"=>"2", "html_views"=>"186"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"56", "xml_views"=>"1", "html_views"=>"425"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"109", "xml_views"=>"1", "html_views"=>"106"}

PMC Usage Stats

  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"24", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"67", "full-text"=>"58", "pdf"=>"39", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"221", "full-text"=>"333", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
Loading … Spinner
There are currently no alerts