The Plant Pathogen Pseudomonas syringae pv. tomato Is Genetically Monomorphic and under Strong Selection to Evade Tomato Immunity
- Publication Date
- August 25, 2011
- Journal
- PLOS Pathogens
- Authors
- Rongman Cai, James Lewis, Shuangchun Yan, Haijie Liu, et al
- Volume
- 7
- Issue
- 8
- Pages
- e1002130
- DOI
- https://dx.plos.org/10.1371/journal.ppat.1002130
- Publisher URL
- http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1002130
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/21901088
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161960
- Europe PMC
- http://europepmc.org/abstract/MED/21901088
- Web of Science
- 000294298100002
- Scopus
- 80052380439
- Mendeley
- http://www.mendeley.com/research/plant-pathogen-pseudomonas-syringae-pv-tomato-genetically-monomorphic-under-strong-selection-evade-t
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Mendeley | Further Information
{"title"=>"The plant pathogen pseudomonas syringae pv. tomato is genetically monomorphic and under strong selection to evade tomato immunity", "type"=>"journal", "authors"=>[{"first_name"=>"Rongman", "last_name"=>"Cai", "scopus_author_id"=>"23766769200"}, {"first_name"=>"James", "last_name"=>"Lewis", "scopus_author_id"=>"57198518708"}, {"first_name"=>"Shuangchun", "last_name"=>"Yan", "scopus_author_id"=>"23096777600"}, {"first_name"=>"Haijie", "last_name"=>"Liu", "scopus_author_id"=>"55736147900"}, {"first_name"=>"Christopher R.", "last_name"=>"Clarke", "scopus_author_id"=>"35336240700"}, {"first_name"=>"Francesco", "last_name"=>"Campanile", "scopus_author_id"=>"26040520200"}, {"first_name"=>"Nalvo F.", "last_name"=>"Almeida", "scopus_author_id"=>"7003469056"}, {"first_name"=>"David J.", "last_name"=>"Studholme", "scopus_author_id"=>"6603689075"}, {"first_name"=>"Magdalen", "last_name"=>"Lindeberg", "scopus_author_id"=>"6603852894"}, {"first_name"=>"David", "last_name"=>"Schneider", "scopus_author_id"=>"35238839600"}, {"first_name"=>"Massimo", "last_name"=>"Zaccardelli", "scopus_author_id"=>"24330316200"}, {"first_name"=>"Joao C.", "last_name"=>"Setubal", "scopus_author_id"=>"6602400333"}, {"first_name"=>"Nadia P.", "last_name"=>"Morales-Lizcano", "scopus_author_id"=>"49663966100"}, {"first_name"=>"Adriana", "last_name"=>"Bernal", "scopus_author_id"=>"7006612034"}, {"first_name"=>"Gitta", "last_name"=>"Coaker", "scopus_author_id"=>"6506517199"}, {"first_name"=>"Christy", "last_name"=>"Baker", "scopus_author_id"=>"57198875510"}, {"first_name"=>"Carol L.", "last_name"=>"Bender", "scopus_author_id"=>"7102455519"}, {"first_name"=>"Scotland", "last_name"=>"Leman", "scopus_author_id"=>"12242888500"}, {"first_name"=>"Boris A.", "last_name"=>"Vinatzer", "scopus_author_id"=>"6602210736"}], "year"=>2011, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-80052380439", "pmid"=>"21901088", "sgr"=>"80052380439", "doi"=>"10.1371/journal.ppat.1002130", "isbn"=>"1553-7374 (Electronic)\\n1553-7366 (Linking)", "issn"=>"15537366", "pui"=>"362475571"}, "id"=>"14f0621a-3a2b-3e67-ba77-a97e80994aff", "abstract"=>"Recently, genome sequencing of many isolates of genetically monomorphic bacterial human pathogens has given new insights into pathogen microevolution and phylogeography. Here, we report a genome-based micro-evolutionary study of a bacterial plant pathogen, Pseudomonas syringae pv. tomato. Only 267 mutations were identified between five sequenced isolates in 3,543,009 nt of analyzed genome sequence, which suggests a recent evolutionary origin of this pathogen. Further analysis with genome-derived markers of 89 world-wide isolates showed that several genotypes exist in North America and in Europe indicating frequent pathogen movement between these world regions. Genome-derived markers and molecular analyses of key pathogen loci important for virulence and motility both suggest ongoing adaptation to the tomato host. A mutational hotspot was found in the type III-secreted effector gene hopM1. These mutations abolish the cell death triggering activity of the full-length protein indicating strong selection for loss of function of this effector, which was previously considered a virulence factor. Two non-synonymous mutations in the flagellin-encoding gene fliC allowed identifying a new microbe associated molecular pattern (MAMP) in a region distinct from the known MAMP flg22. Interestingly, the ancestral allele of this MAMP induces a stronger tomato immune response than the derived alleles. The ancestral allele has largely disappeared from today's Pto populations suggesting that flagellin-triggered immunity limits pathogen fitness even in highly virulent pathogens. An additional non-synonymous mutation was identified in flg22 in South American isolates. Therefore, MAMPs are more variable than expected differing even between otherwise almost identical isolates of the same pathogen strain.", "link"=>"http://www.mendeley.com/research/plant-pathogen-pseudomonas-syringae-pv-tomato-genetically-monomorphic-under-strong-selection-evade-t", "reader_count"=>143, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>11, "Researcher"=>40, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>4, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>8, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>11, "Researcher"=>40, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>4, "Student > Master"=>12, "Other"=>2, "Student > Bachelor"=>8, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>13, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>11, "Mathematics"=>1, "Agricultural and Biological Sciences"=>106, "Medicine and Dentistry"=>2, "Design"=>1, "Neuroscience"=>1, "Arts and Humanities"=>1, "Chemistry"=>2, "Computer Science"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>106}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>13}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Greece"=>1, "Argentina"=>1, "United States"=>2, "Brazil"=>1, "Uganda"=>1, "France"=>1, "Australia"=>1, "Germany"=>1}, "group_count"=>7}CrossRef
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Scopus | Further Information
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- {"id"=>"430867288137297920", "text"=>"@surt_lab @JimAlfano1 Agreed. Also, the fliC mutations in P. syringae tomato. Love this paper http://t.co/TWIwpS5Stc", "created_at"=>"2014-02-05T00:55:41Z", "user"=>"KamounLab", "user_name"=>"Kamoun Lab @ TSL", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1172136536/KamounLab_normal.jpg"}
- {"id"=>"756246398098518016", "text"=>"BV: Pseudomonas syringae pv tomato (Pto) genetic diversity world wide https://t.co/FDzGVyFtwj #MPMI16", "created_at"=>"2016-07-21T21:56:06Z", "user"=>"schwessinger", "user_name"=>"BenjaminSchwessinger", "user_profile_image"=>"http://pbs.twimg.com/profile_images/754447486895271938/6sNYQ7jG_normal.jpg"}
- {"id"=>"756248043645579264", "text"=>"RT @schwessinger: BV: Pseudomonas syringae pv tomato (Pto) genetic diversity world wide https://t.co/FDzGVyFtwj #MPMI16", "created_at"=>"2016-07-21T22:02:38Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459394339945197568/BuJQyL0D_normal.jpeg"}
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- {"month"=>"4", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"121"}
- {"month"=>"5", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"119"}
- {"month"=>"6", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"101"}
- {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"69"}
- {"month"=>"8", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"86"}
- {"month"=>"9", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"131"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"112"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"83"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"85"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"72"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"40"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"54"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"56"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"50"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"63"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"81"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"91"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"73"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"60"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"60"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"59"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"96"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"95"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"99"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"62"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"74"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"52"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"46"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"64"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"75"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"45"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"56"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"47"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"66"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"64"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"69"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"47"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"4", "html_views"=>"66"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"74"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"53"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"71"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"38"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"39"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"28"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"48"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"48"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"2", "html_views"=>"67"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"50"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"45"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"67"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"79"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"56"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"2", "html_views"=>"59"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"54"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"88"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"69"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"75"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"69"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"49"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"71"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"48"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"95"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"43", "xml_views"=>"4", "html_views"=>"90"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"34", "xml_views"=>"2", "html_views"=>"76"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"75"}
- {"month"=>"2", "year"=>"2021", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"83"}
- {"month"=>"3", "year"=>"2021", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
PMC Usage Stats | Further Information
- {"scanned-page-browse"=>"0", "month"=>"9", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"62", "unique-ip"=>"58", "pdf"=>"58", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"10", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"31", "year"=>"2011", "pdf"=>"22", "unique-ip"=>"30", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"63", "unique-ip"=>"38", "pdf"=>"19", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"3"}
- {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"14", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"29", "unique-ip"=>"29", "pdf"=>"16", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"32", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"36", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"27", "unique-ip"=>"27", "pdf"=>"13", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"4"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "year"=>"2012", "pdf"=>"6", "unique-ip"=>"13", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "unique-ip"=>"16", "pdf"=>"11", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"20", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"20", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"2"}
- {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"6", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"7", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"17", "full-text"=>"10", "pdf"=>"7", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"17", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"13", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"23", "full-text"=>"18", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"24", "full-text"=>"14", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"30", "full-text"=>"14", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"21", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"21", "full-text"=>"28", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
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Relative Metric
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