Sleeping with the Enemy: How Intracellular Pathogens Cope with a Macrophage Lifestyle
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{"title"=>"Sleeping with the enemy: How intracellular pathogens cope with a macrophage lifestyle", "type"=>"journal", "authors"=>[{"first_name"=>"Emily P.", "last_name"=>"Thi", "scopus_author_id"=>"9233194700"}, {"first_name"=>"Ulrike", "last_name"=>"Lambertz", "scopus_author_id"=>"9942679900"}, {"first_name"=>"Neil E.", "last_name"=>"Reiner", "scopus_author_id"=>"7005191150"}], "year"=>2012, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-84861216079", "sgr"=>"84861216079", "issn"=>"15537366", "doi"=>"10.1371/journal.ppat.1002551", "pmid"=>"22457616", "isbn"=>"1553-7374 (Electronic)\\n1553-7366 (Linking)", "pui"=>"364837121"}, "id"=>"5cfe1027-2636-304b-a196-85ee7b012725", "abstract"=>"Intracellular pathogens are a major cause of global morbidity and mortality. While this alone establishes their medical importance, they are also a focus of special interest because of their unique lifestyles. Many of these organisms have evolved to reside within the hostile environment of macrophages. Given that these innate immune effector cells are normally programmed to destroy ingested prey and promote the development of adaptive immunity, this is one of the ultimate paradoxes in the study of host–pathogen interactions. The success of these microbes is dependent on diverse strategies including the disruption of macrophage cell regulation, the ability to nullify macrophage microbicidal effector mechanisms, and other special adaptations to an intracellular lifestyle. Here, we review a series of well established survival paradigms that have emerged that illustrate this behaviour.", "link"=>"http://www.mendeley.com/research/sleeping-enemy-intracellular-pathogens-cope-macrophage-lifestyle", "reader_count"=>148, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>9, "Researcher"=>38, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>6, "Student > Master"=>17, "Other"=>2, "Student > Bachelor"=>8, "Lecturer > Senior Lecturer"=>3, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>9, "Researcher"=>38, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>6, "Student > Master"=>17, "Other"=>2, "Student > Bachelor"=>8, "Lecturer > Senior Lecturer"=>3, "Professor"=>4}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>5, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>16, "Agricultural and Biological Sciences"=>92, "Medicine and Dentistry"=>5, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>22}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>22}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>92}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>16}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "Argentina"=>2, "United States"=>5, "United Kingdom"=>1, "Portugal"=>1, "Canada"=>1, "Venezuela"=>1, "Ireland"=>1, "Brazil"=>3, "South Africa"=>2, "Mexico"=>1, "Slovenia"=>1, "Australia"=>1, "Chile"=>1, "Peru"=>1, "Germany"=>1}, "group_count"=>3}

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