CRISPR-Cas Immunity against Phages: Its Effects on the Evolution and Survival of Bacterial Pathogens
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{"title"=>"CRISPR-Cas Immunity against Phages: Its Effects on the Evolution and Survival of Bacterial Pathogens", "type"=>"journal", "authors"=>[{"first_name"=>"Luciano A.", "last_name"=>"Marraffini", "scopus_author_id"=>"6506120061"}], "year"=>2013, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "scopus"=>"2-s2.0-84892846048", "sgr"=>"84892846048", "pui"=>"372180035", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "pmid"=>"24348245", "doi"=>"10.1371/journal.ppat.1003765"}, "id"=>"032e0c49-0b9c-31e0-a0ac-84ea4e8d80c5", "abstract"=>"The spacer sequence is transcribed and processed to generate a small antisense RNA (the CRISPR RNA or crRNA) (Figure 1B) [6] that is used as a guide for the recognition and destruction of the invader in subsequent infections (Figure 1C) [7]. [...]spacer acquisition immunizes the bacterium and its progeny against the virus from which it was taken. Because spacers are incorporated in sequential order, CRISPR loci reflect the history of viral infection of the host.", "link"=>"http://www.mendeley.com/research/crisprcas-immunity-against-phages-effects-evolution-survival-bacterial-pathogens", "reader_count"=>132, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>8, "Researcher"=>35, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>31, "Student > Postgraduate"=>7, "Student > Master"=>25, "Other"=>6, "Student > Bachelor"=>8, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>8, "Researcher"=>35, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>31, "Student > Postgraduate"=>7, "Student > Master"=>25, "Other"=>6, "Student > Bachelor"=>8, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>21, "Agricultural and Biological Sciences"=>83, "Medicine and Dentistry"=>2, "Arts and Humanities"=>1, "Physics and Astronomy"=>1, "Chemistry"=>2, "Social Sciences"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>11, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>2}, "Social Sciences"=>{"Social Sciences"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>11}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>83}, "Computer Science"=>{"Computer Science"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>21}, "Unspecified"=>{"Unspecified"=>5}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Argentina"=>1, "United States"=>7, "China"=>1, "United Kingdom"=>1, "South Africa"=>1, "Israel"=>1, "Australia"=>1, "Germany"=>1}, "group_count"=>3}

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Figshare

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