Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers
- Publication Date
- June 11, 2015
- Journal
- PLOS Pathogens
- Authors
- Enrique Martin Gayo, Maria Jose Buzon, Zhengyu Ouyang, Taylor Hickman, et al
- Volume
- 11
- Issue
- 6
- Pages
- e1004930
- DOI
- https://dx.plos.org/10.1371/journal.ppat.1004930
- Publisher URL
- http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1004930
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/26067651
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466270
- Europe PMC
- http://europepmc.org/abstract/MED/26067651
- Web of Science
- 000357400900023
- Scopus
- 84936741267
- Mendeley
- http://www.mendeley.com/research/potent-cellintrinsic-immune-responses-dendritic-cells-facilitate-hiv1specific-t-cell-immunity-hiv1-e
Loading … 

Events
Loading … 

Mendeley | Further Information
{"title"=>"Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers", "type"=>"journal", "authors"=>[{"first_name"=>"Enrique", "last_name"=>"Martin-Gayo", "scopus_author_id"=>"16444765000"}, {"first_name"=>"Maria Jose", "last_name"=>"Buzon", "scopus_author_id"=>"25654516300"}, {"first_name"=>"Zhengyu", "last_name"=>"Ouyang", "scopus_author_id"=>"55786268000"}, {"first_name"=>"Taylor", "last_name"=>"Hickman", "scopus_author_id"=>"56715451500"}, {"first_name"=>"Jacqueline", "last_name"=>"Cronin", "scopus_author_id"=>"56715034100"}, {"first_name"=>"Dina", "last_name"=>"Pimenova", "scopus_author_id"=>"56716435200"}, {"first_name"=>"Bruce D.", "last_name"=>"Walker", "scopus_author_id"=>"7402209193"}, {"first_name"=>"Mathias", "last_name"=>"Lichterfeld", "scopus_author_id"=>"6602189737"}, {"first_name"=>"Xu G.", "last_name"=>"Yu", "scopus_author_id"=>"7404115518"}], "year"=>2015, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-84936741267", "pmid"=>"26067651", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "doi"=>"10.1371/journal.ppat.1004930", "issn"=>"15537374", "sgr"=>"84936741267", "pui"=>"605161842"}, "id"=>"7603061b-22bb-3a82-89dd-2488ec4bff52", "abstract"=>"The majority of HIV-1 elite controllers (EC) restrict HIV-1 replication through highly functional HIV-1-specific T cell responses, but mechanisms supporting the evolution of effective HIV-1-specific T cell immunity in these patients remain undefined. Cytosolic immune recognition of HIV-1 in conventional dendritic cells (cDC) can facilitate priming and expansion of HIV-1-specific T cells; however, HIV-1 seems to be able to avoid intracellular immune recognition in cDCs in most infected individuals. Here, we show that exposure of cDCs from EC to HIV-1 leads to a rapid and sustained production of type I interferons and upregulation of several interferon-stimulated effector genes. Emergence of these cell-intrinsic immune responses was associated with a reduced induction of SAMHD1 and LEDGF/p75, and an accumulation of viral reverse transcripts, but inhibited by pharmacological blockade of viral reverse transcription or siRNA-mediated silencing of the cytosolic DNA sensor cGAS. Importantly, improved cell-intrinsic immune recognition of HIV-1 in cDCs from elite controllers translated into stronger abilities to stimulate and expand HIV-1-specific CD8 T cell responses. These data suggest an important role of cell-intrinsic type I interferon secretion in dendritic cells for the induction of effective HIV-1-specific CD8 T cells, and may be helpful for eliciting functional T cell immunity against HIV-1 for preventative or therapeutic clinical purposes.", "link"=>"http://www.mendeley.com/research/potent-cellintrinsic-immune-responses-dendritic-cells-facilitate-hiv1specific-t-cell-immunity-hiv1-e", "reader_count"=>53, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>3, "Student > Doctoral Student"=>3, "Researcher"=>12, "Student > Ph. D. Student"=>12, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>5, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>3, "Student > Doctoral Student"=>3, "Researcher"=>12, "Student > Ph. D. Student"=>12, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>5, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Mathematics"=>1, "Agricultural and Biological Sciences"=>22, "Medicine and Dentistry"=>11, "Neuroscience"=>1, "Psychology"=>1, "Immunology and Microbiology"=>9, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Italy"=>1, "South Africa"=>1, "United Kingdom"=>1}, "group_count"=>1}CrossRef
- http://doi.org/10.4049/jimmunol.1500683
- http://doi.org/10.1007/s40506-018-0158-8
- http://doi.org/10.3389/fimmu.2019.02677
- http://doi.org/10.1016/j.virusres.2016.10.016
- http://doi.org/10.1097/QAD.0000000000002196
- http://doi.org/10.1038/ni.3267
- http://doi.org/10.1016/j.chom.2016.03.001
- http://doi.org/10.1016/j.cellimm.2016.09.003
- http://doi.org/10.1016/j.coviro.2017.01.001
- http://doi.org/10.1371/journal.pone.0160251
- http://doi.org/10.7448/IAS.19.1.21136
- http://doi.org/10.3390/v8050123
- http://doi.org/10.1016/j.celrep.2016.09.023
- http://doi.org/10.1074/jbc.M116.752584
- http://doi.org/10.3389/fimmu.2018.02719
- http://doi.org/10.3389/fimmu.2018.00299
- http://doi.org/10.1016/j.tim.2015.08.002
- http://doi.org/10.1007/s12026-016-8862-2
- http://doi.org/10.1128/JVI.00366-18
- http://doi.org/10.1186/s13059-017-1385-x
- http://doi.org/10.1186/s12879-015-1092-8
- http://doi.org/10.3389/fimmu.2019.01306
- http://doi.org/10.1128/JVI.02278-15
- http://doi.org/10.1016/j.celrep.2016.07.002
- http://doi.org/10.1038/nri.2016.78
- http://doi.org/10.1038/s41590-019-0406-1
- http://doi.org/10.1186/s12977-016-0248-y
- http://doi.org/10.1007/s11904-017-0345-0
- http://doi.org/10.1146/annurev-immunol-051116-052155
- http://doi.org/10.3389/fimmu.2017.00244
- http://doi.org/10.3389/fimmu.2019.02485
- http://doi.org/10.1093/infdis/jiw163
- http://doi.org/10.1172/jci.insight.89574
- http://doi.org/10.3389/fimmu.2018.02876
- http://doi.org/10.1128/JVI.00051-17
Scopus | Further Information
{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84936741267"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84936741267?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84936741267&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84936741267&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84936741267", "dc:identifier"=>"SCOPUS_ID:84936741267", "eid"=>"2-s2.0-84936741267", "dc:title"=>"Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers", "dc:creator"=>"Martin-Gayo E.", "prism:publicationName"=>"PLoS Pathogens", "prism:issn"=>"15537366", "prism:eIssn"=>"15537374", "prism:volume"=>"11", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-01-01", "prism:coverDisplayDate"=>"1 June 2015", "prism:doi"=>"10.1371/journal.ppat.1004930", "citedby-count"=>"35", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Massachusetts Institute of Technology", "affiliation-city"=>"Cambridge", "affiliation-country"=>"United States"}], "pubmed-id"=>"26067651", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1004930", "source-id"=>"4000151809", "openaccess"=>"1", "openaccessFlag"=>true}Article Coverage
- {"referral"=>"http://www.eurekalert.org/pub_releases/2015-06/p-tro060415.php", "language"=>"", "title"=>"The role of dendritic cells in keeping HIV in check without drugs", "type"=>"Press Release", "publication"=>"PLOS", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.utsandiego.com/news/2015/jun/11/hiv-dendritic-elite-controllers/?#article-copy", "language"=>"", "title"=>"HIV resistance clue found: 'Elite controllers' mount stronger response from dendritic immune cells", "type"=>"News", "publication"=>"The San Diego Union-Tribune", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.newscientist.com/article/dn27708-some-people-can-resist-the-ravages-of-hiv--heres-how.html#.VXnTU0YeqkI", "language"=>"", "title"=>"Some people can resist the ravages of HIV – here's how", "type"=>"News", "publication"=>"New Scientist", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://ragoninstitute.org/2015/06/dendritic-cells-of-controllers-recognize-mount-defense-against-hiv/", "language"=>"", "title"=>"Dendritic Cells of Controllers Recognize, Mount Defense Against HIV", "type"=>"Press Release", "publication"=>"Ragon Institute", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.abc.es/salud/noticias/20150612/abci-controlador-elite-plos-201506111838.html", "language"=>"Spanish", "title"=>"Descubren una clave para que las personas con VIH controlen la infección de forma natural", "type"=>"News", "publication"=>"ABC.es", "published_on"=>"2015-06-12T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.massgeneral.org/about/pressrelease.aspx?id=1819", "language"=>"", "title"=>"Dendritic cells of elite controllers able to recognize, mount defense against HIV", "type"=>"Press Release", "publication"=>"Massachusetts General Hospital", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.newscientist.com/article/dn27708-some-people-can-resist-the-ravages-of-hiv--heres-how.html", "language"=>"English", "title"=>"Some people can resist the ravages of HIV – here's how - health - 11 June 2015 - New Scientist", "type"=>"News", "publication"=>"", "published_on"=>"2015-06-16T00:00:00Z", "link_state"=>"REJECTED"}
- {"referral"=>"http://www.massgeneral.org/about/pressrelease.aspx?id=1819", "language"=>"", "title"=>"Dendritic cells of elite controllers able to recognize, mount defense against HIV", "type"=>"Press Release", "publication"=>"Massachusetts General Hospital", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"REJECTED"}
- {"referral"=>"http://runrun.es/nacional/inbox/207839/descubren-una-clave-para-que-las-personas-con-vih-controlen-la-infeccion-de-forma-natural.html", "language"=>"Spanish", "title"=>"Descubren una clave para que las personas con VIH controlen la infección de forma natural", "type"=>"News", "publication"=>"runrun.es", "published_on"=>"2015-06-15T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.hcplive.com/medical-news/researchers-discover-key-characteristics-of-hiv-elite-controllers", "language"=>"", "title"=>"Researchers Discover Key Characteristics of HIV Elite Controllers", "type"=>"News", "publication"=>"MD Magazine", "published_on"=>"2015-06-12T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.hivequal.org/hiv-equal-online/how-elite-controllers-may-hold-the-genetic-key-to-an-hiv-cure", "language"=>"", "title"=>"How \"Elite Controllers\" May Hold the Genetic Key to an HIV Cure", "type"=>"News", "publication"=>"HIV Equal", "published_on"=>"2015-06-11T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.imstilljosh.com/hiv-elite-controllers-cure/", "language"=>"", "title"=>"Are We Medicating Our Potential HIV Cure?", "type"=>"Blog", "publication"=>"I'm Still Josh", "published_on"=>"2015-06-12T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://tech.sme.sk/c/7862695/percento-pacientov-sa-vie-prirodzene-branit-virusu-hiv.html", "language"=>"", "title"=>"Percento pacientov sa vie prirodzene brániť vírusu HIV | Človek | tech.sme.sk", "type"=>"Discussion board", "publication"=>"SME - Petit Press, a.s.", "published_on"=>"2015-06-18T00:00:00Z", "link_state"=>"REJECTED"}
- {"referral"=>"http://hms.harvard.edu//news/hiv-paradox", "language"=>"English", "title"=>"HIV Paradox", "type"=>"Press Release", "publication"=>"Harvard Medical School", "published_on"=>"2015-06-29T00:00:00Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.sciencedaily.com/releases/2015/06/150611144436.htm", "language"=>"English", "title"=>"Dendritic cells of elite controllers able to recognize, mount defense against HIV: Rare natural ability to control HIV replication -- ScienceDaily", "type"=>"News", "publication"=>"", "published_on"=>"2015-07-16T00:00:00Z", "link_state"=>"REJECTED"}
- {"referral"=>"http://medicalxpress.com/news/2015-06-dendritic-cells-elite-mount-defense.html", "language"=>"English", "title"=>"Dendritic cells of elite controllers able to recognize, mount defense against HIV", "type"=>"News", "publication"=>"", "published_on"=>"2015-08-06T00:00:00Z", "link_state"=>"REJECTED"}
Article Coverage Curated
- {"referral"=>"http://www.eurekalert.org/pub_releases/2015-06/p-tro060415.php", "language"=>"", "title"=>"The role of dendritic cells in keeping HIV in check without drugs", "type"=>"Press Release", "publication"=>"PLOS", "published_on"=>"2015-06-11T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.utsandiego.com/news/2015/jun/11/hiv-dendritic-elite-controllers/?#article-copy", "language"=>"", "title"=>"HIV resistance clue found: 'Elite controllers' mount stronger response from dendritic immune cells", "type"=>"News", "publication"=>"The San Diego Union-Tribune", "published_on"=>"2015-06-11T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.newscientist.com/article/dn27708-some-people-can-resist-the-ravages-of-hiv--heres-how.html#.VXnTU0YeqkI", "language"=>"", "title"=>"Some people can resist the ravages of HIV – here's how", "type"=>"News", "publication"=>"New Scientist", "published_on"=>"2015-06-11T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://ragoninstitute.org/2015/06/dendritic-cells-of-controllers-recognize-mount-defense-against-hiv/", "language"=>"", "title"=>"Dendritic Cells of Controllers Recognize, Mount Defense Against HIV", "type"=>"Press Release", "publication"=>"Ragon Institute", "published_on"=>"2015-06-11T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.abc.es/salud/noticias/20150612/abci-controlador-elite-plos-201506111838.html", "language"=>"Spanish", "title"=>"Descubren una clave para que las personas con VIH controlen la infección de forma natural", "type"=>"News", "publication"=>"ABC.es", "published_on"=>"2015-06-12T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.massgeneral.org/about/pressrelease.aspx?id=1819", "language"=>"", "title"=>"Dendritic cells of elite controllers able to recognize, mount defense against HIV", "type"=>"Press Release", "publication"=>"Massachusetts General Hospital", "published_on"=>"2015-06-11T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://runrun.es/nacional/inbox/207839/descubren-una-clave-para-que-las-personas-con-vih-controlen-la-infeccion-de-forma-natural.html", "language"=>"Spanish", "title"=>"Descubren una clave para que las personas con VIH controlen la infección de forma natural", "type"=>"News", "publication"=>"runrun.es", "published_on"=>"2015-06-15T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.hcplive.com/medical-news/researchers-discover-key-characteristics-of-hiv-elite-controllers", "language"=>"", "title"=>"Researchers Discover Key Characteristics of HIV Elite Controllers", "type"=>"News", "publication"=>"MD Magazine", "published_on"=>"2015-06-12T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.hivequal.org/hiv-equal-online/how-elite-controllers-may-hold-the-genetic-key-to-an-hiv-cure", "language"=>"", "title"=>"How \"Elite Controllers\" May Hold the Genetic Key to an HIV Cure", "type"=>"News", "publication"=>"HIV Equal", "published_on"=>"2015-06-11T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://www.imstilljosh.com/hiv-elite-controllers-cure/", "language"=>"", "title"=>"Are We Medicating Our Potential HIV Cure?", "type"=>"Blog", "publication"=>"I'm Still Josh", "published_on"=>"2015-06-12T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"referral"=>"http://hms.harvard.edu//news/hiv-paradox", "language"=>"English", "title"=>"HIV Paradox", "type"=>"Press Release", "publication"=>"Harvard Medical School", "published_on"=>"2015-06-29T00:00:00.000Z", "link_state"=>"APPROVED"}
- {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplospathogens%2Farticle%3Fid%3D10.1371%252Fjournal.ppat.1004930", "share_count"=>15, "like_count"=>21, "comment_count"=>0, "click_count"=>0, "total_count"=>36}
- {"id"=>"609063043629092865", "text"=>"Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute http://t.co/CvgB7c8HNM", "created_at"=>"2015-06-11T18:22:00Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459394339945197568/BuJQyL0D_normal.jpeg"}
- {"id"=>"609063213435645952", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-11T18:22:40Z", "user"=>"Kenzibit", "user_name"=>"Ken Yaw Agyeman-Badu", "user_profile_image"=>"http://pbs.twimg.com/profile_images/589238684370669569/9K74ipZE_normal.jpg"}
- {"id"=>"609063357019127809", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-11T18:23:14Z", "user"=>"ragoninstitute", "user_name"=>"ragon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/494207732052815874/VvVtWtgU_normal.jpeg"}
- {"id"=>"609064756721242112", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-11T18:28:48Z", "user"=>"PLOS", "user_name"=>"PLOS", "user_profile_image"=>"http://pbs.twimg.com/profile_images/553318804122370048/0HTyc2Ot_normal.jpeg"}
- {"id"=>"609069154205900800", "text"=>"Role of dendritic cells in keeping #HIV in check without drugs http://t.co/bD4e1MJaI2 Research @PLOS @ragoninstitute http://t.co/nUwtu0zvt4\"", "created_at"=>"2015-06-11T18:46:16Z", "user"=>"pvalente", "user_name"=>"Pasquale Valente", "user_profile_image"=>"http://pbs.twimg.com/profile_images/438819187545239553/rx66v1UT_normal.jpeg"}
- {"id"=>"609070368444297216", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-11T18:51:06Z", "user"=>"ScientistSoph", "user_name"=>"Sophie Something", "user_profile_image"=>"http://pbs.twimg.com/profile_images/516197424759459840/xJlzJovG_normal.jpeg"}
- {"id"=>"609091965205012481", "text"=>"Study suggests dendritic cells of HIV elite responders are efficient at secretion of interferon. http://t.co/Y9A2gCWyPD", "created_at"=>"2015-06-11T20:16:55Z", "user"=>"ScienceConfab", "user_name"=>"ScienceConfab", "user_profile_image"=>"http://pbs.twimg.com/profile_images/483619807816732673/okYQa4Te_normal.jpeg"}
- {"id"=>"609095358166085632", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-11T20:30:24Z", "user"=>"nate_palm", "user_name"=>"Nathan Palmer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/573208142466531328/U44DDU_J_normal.jpeg"}
- {"id"=>"609119644083818496", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-11T22:06:54Z", "user"=>"dzavr", "user_name"=>"Dina", "user_profile_image"=>"http://pbs.twimg.com/profile_images/488179534853062656/2sl-1G7f_normal.jpeg"}
- {"id"=>"609424495833559042", "text"=>"Some people can resist the ravages of #HIV: here's how @newscientist http://t.co/dn5IlR3bKr\nResearch @PLOS http://t.co/nSjf8BL9J7", "created_at"=>"2015-06-12T18:18:17Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459394339945197568/BuJQyL0D_normal.jpeg"}
- {"id"=>"609424739375915009", "text"=>"RT @PLOSPathogens: Some people can resist the ravages of #HIV: here's how @newscientist http://t.co/dn5IlR3bKr\nResearch @PLOS http://t.co/n…", "created_at"=>"2015-06-12T18:19:15Z", "user"=>"Markusmicrobius", "user_name"=>"Prof Mark Fielder", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3371635456/0fc5932628abec8c1449026f1146e673_normal.jpeg"}
- {"id"=>"609428598597001216", "text"=>"RT @PLOSPathogens: Some people can resist the ravages of #HIV: here's how @newscientist http://t.co/dn5IlR3bKr\nResearch @PLOS http://t.co/n…", "created_at"=>"2015-06-12T18:34:35Z", "user"=>"BIOCIENCIA2013", "user_name"=>"BIOCIENCIA", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000300217090/9b25d5f581a95fff46afd4d8d0d0aad0_normal.jpeg"}
- {"id"=>"609435269742362625", "text"=>"RT @PLOSPathogens: Some people can resist the ravages of #HIV: here's how @newscientist http://t.co/dn5IlR3bKr\nResearch @PLOS http://t.co/n…", "created_at"=>"2015-06-12T19:01:05Z", "user"=>"ymillerioux", "user_name"=>"Yoann Millerioux ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/601068134255198209/mZgjdDOE_normal.jpg"}
- {"id"=>"609498027858903040", "text"=>"Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 E http://t.co/t3MvaGAIrF", "created_at"=>"2015-06-12T23:10:28Z", "user"=>"mdnetsolutions", "user_name"=>"MDnetSolutions ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/477121892348731392/WFGYGN1H_normal.jpeg"}
- {"id"=>"609737506423218176", "text"=>"Clark Kent Dendritic Cell Response = #HIV Elite Controller #Superman Ability. The study: http://t.co/IowSTIayPJ", "created_at"=>"2015-06-13T15:02:04Z", "user"=>"SoCogEffyias", "user_name"=>"Kenneth Poon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000603081677/28c7d3e25f2b75c588d1a49772ea94fb_normal.jpeg"}
- {"id"=>"609737599159304192", "text"=>"RT @PLOSPathogens: Some people can resist the ravages of #HIV: here's how @newscientist http://t.co/dn5IlR3bKr\nResearch @PLOS http://t.co/n…", "created_at"=>"2015-06-13T15:02:26Z", "user"=>"SoCogEffyias", "user_name"=>"Kenneth Poon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000603081677/28c7d3e25f2b75c588d1a49772ea94fb_normal.jpeg"}
- {"id"=>"610060894941409280", "text"=>"RT @PLOSPathogens: Some people can resist the ravages of #HIV: here's how @newscientist http://t.co/dn5IlR3bKr\nResearch @PLOS http://t.co/n…", "created_at"=>"2015-06-14T12:27:06Z", "user"=>"S_Lhomme", "user_name"=>"Sebastien Lhomme", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_1_normal.png"}
- {"id"=>"610150710227914752", "text"=>"RT @PLOSPathogens: Role of dendritic cells in keeping #HIV in check without drugs http://t.co/YBvKbOM40k Research @PLOS @ragoninstitute htt…", "created_at"=>"2015-06-14T18:24:00Z", "user"=>"FaisalSS_MD", "user_name"=>"Faisal S.S.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/516691942072016897/zsGiiNM8_normal.jpeg"}
- {"id"=>"610864277604421638", "text"=>"How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://t.co/nSjf8BtyRz", "created_at"=>"2015-06-16T17:39:27Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459394339945197568/BuJQyL0D_normal.jpeg"}
- {"id"=>"610866957835980800", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T17:50:06Z", "user"=>"taliaswartz", "user_name"=>"Talia H. Swartz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/552924021667684352/mb1DKj89_normal.jpeg"}
- {"id"=>"610868591731298304", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T17:56:36Z", "user"=>"jshrima", "user_name"=>"Joanne Shrimpton", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1653539853/Joanne_normal.jpg"}
- {"id"=>"610871557024563200", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T18:08:23Z", "user"=>"Retrovirology", "user_name"=>"Retrovirology", "user_profile_image"=>"http://pbs.twimg.com/profile_images/542780676253048832/V-9ryk9h_normal.png"}
- {"id"=>"610875584240033792", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T18:24:23Z", "user"=>"cggbamford", "user_name"=>"Connor Bamford", "user_profile_image"=>"http://pbs.twimg.com/profile_images/592778109335764992/9uakw1eF_normal.jpg"}
- {"id"=>"610879125461573632", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T18:38:27Z", "user"=>"PLOS", "user_name"=>"PLOS", "user_profile_image"=>"http://pbs.twimg.com/profile_images/553318804122370048/0HTyc2Ot_normal.jpeg"}
- {"id"=>"610880215305310209", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T18:42:47Z", "user"=>"CogniKoi", "user_name"=>"CogniKoi", "user_profile_image"=>"http://pbs.twimg.com/profile_images/588358252749946880/ka-bb14B_normal.png"}
- {"id"=>"610881716446740480", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T18:48:45Z", "user"=>"Sahelanth", "user_name"=>"James Pitt", "user_profile_image"=>"http://pbs.twimg.com/profile_images/474989133895458816/37tsAPPD_normal.jpeg"}
- {"id"=>"610882769288343556", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T18:52:56Z", "user"=>"DavidHeitz", "user_name"=>"David Heitz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/574279254214496256/PJZIU_vL_normal.jpeg"}
- {"id"=>"610885536102907904", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-16T19:03:56Z", "user"=>"SoCogEffyias", "user_name"=>"Kenneth Poon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000603081677/28c7d3e25f2b75c588d1a49772ea94fb_normal.jpeg"}
- {"id"=>"611360747403259904", "text"=>"#HIV resistance clue: 'Elite controllers' mount stronger dendritic immune cell responses: 1 http://t.co/sdYtnlWE3i 2 http://t.co/jbmzzjdspA", "created_at"=>"2015-06-18T02:32:15Z", "user"=>"dbarthjones", "user_name"=>"Daniel Barth-Jones", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2364130865/55svxk70p5n6a5s1xuur_normal.jpeg"}
- {"id"=>"611384937795616768", "text"=>"RT @PLOSPathogens: How \"Elite Controllers\" May Hold the Genetic Key to an #HIV Cure @HIVequal http://t.co/LUaKRJb5dG Research @PLOS http://…", "created_at"=>"2015-06-18T04:08:22Z", "user"=>"Eleryhana", "user_name"=>"EleryhanaM", "user_profile_image"=>"http://pbs.twimg.com/profile_images/591428011817205760/32fv659y_normal.jpg"}
- {"id"=>"613149453755772928", "text"=>"Artículo de investigación acerca de los controladores de élite. VIH positivos. \n\nhttp://t.co/6XTWcVsFwc", "created_at"=>"2015-06-23T00:59:56Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586989000923164673/3bnVFLXy_normal.jpg"}
- {"id"=>"613149986440790016", "text"=>"RESEARCH ARTICLE. \n\nHIV-1 Elite Controllers. \n\nhttp://t.co/6XTWcVsFwc", "created_at"=>"2015-06-23T01:02:03Z", "user"=>"IlindelatorreMD", "user_name"=>"Dr Ilin Gilberto dl", "user_profile_image"=>"http://pbs.twimg.com/profile_images/586989000923164673/3bnVFLXy_normal.jpg"}
- {"id"=>"671890307751927808", "text"=>"Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T03:15:07Z", "user"=>"PLOSPathogens", "user_name"=>"PLOS Pathogens", "user_profile_image"=>"http://pbs.twimg.com/profile_images/459394339945197568/BuJQyL0D_normal.jpeg"}
- {"id"=>"671926823966609409", "text"=>"RT @PLOSPathogens: Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T05:40:13Z", "user"=>"Pierre_Castro", "user_name"=>"Pierre Castro", "user_profile_image"=>"http://pbs.twimg.com/profile_images/665470881615990785/9YkUUkZL_normal.jpg"}
- {"id"=>"672070581118885888", "text"=>"RT @PLOSPathogens: Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T15:11:27Z", "user"=>"PLOS", "user_name"=>"PLOS", "user_profile_image"=>"http://pbs.twimg.com/profile_images/553318804122370048/0HTyc2Ot_normal.jpeg"}
- {"id"=>"672070947122372608", "text"=>"RT @PLOSPathogens: Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T15:12:54Z", "user"=>"HFrancisC", "user_name"=>"Humberto FC", "user_profile_image"=>"http://pbs.twimg.com/profile_images/646326874331869184/fq2Q5Znu_normal.jpg"}
- {"id"=>"672071267286130689", "text"=>"RT @PLOSPathogens: Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T15:14:11Z", "user"=>"ScienceNectar", "user_name"=>"Science Nectar", "user_profile_image"=>"http://pbs.twimg.com/profile_images/667307604570324992/rKy3lan-_normal.jpg"}
- {"id"=>"672079073510875138", "text"=>"RT @PLOSPathogens: Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T15:45:12Z", "user"=>"BIOCIENCIA2013", "user_name"=>"BIOCIENCIA", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000300217090/9b25d5f581a95fff46afd4d8d0d0aad0_normal.jpeg"}
- {"id"=>"672081482605846528", "text"=>"RT @PLOSPathogens: Cell-Intrinsic Immunity to HIV in Dendritic Cells #WorldAIDSDay https://t.co/nSjf8BL9J7", "created_at"=>"2015-12-02T15:54:46Z", "user"=>"lemv24", "user_name"=>"Luis Eduardo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000060593542/aab7ab2153aa0c87bd54bb4c4cc5b2f0_normal.jpeg"}
Counter
- {"month"=>"6", "year"=>"2015", "pdf_views"=>"437", "xml_views"=>"5", "html_views"=>"2807"}
- {"month"=>"7", "year"=>"2015", "pdf_views"=>"109", "xml_views"=>"1", "html_views"=>"473"}
- {"month"=>"8", "year"=>"2015", "pdf_views"=>"71", "xml_views"=>"0", "html_views"=>"258"}
- {"month"=>"9", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"175"}
- {"month"=>"10", "year"=>"2015", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"225"}
- {"month"=>"11", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"190"}
- {"month"=>"12", "year"=>"2015", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"331"}
- {"month"=>"1", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"135"}
- {"month"=>"2", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"137"}
- {"month"=>"3", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"107"}
- {"month"=>"4", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"119"}
- {"month"=>"5", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"109"}
- {"month"=>"6", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"82"}
- {"month"=>"7", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"71"}
- {"month"=>"8", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"114"}
- {"month"=>"9", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"108"}
- {"month"=>"10", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"116"}
- {"month"=>"11", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"89"}
- {"month"=>"12", "year"=>"2016", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"78"}
- {"month"=>"1", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"89"}
- {"month"=>"2", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"79"}
- {"month"=>"3", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"77"}
- {"month"=>"4", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
- {"month"=>"5", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"71"}
- {"month"=>"6", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"7", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"65"}
- {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"37"}
- {"month"=>"9", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"43"}
- {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"67"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"62"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"47"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"24"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"22"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"35"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"4", "html_views"=>"15"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"4", "html_views"=>"15"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"18"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"33"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"15"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"27"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"22"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"21"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"20"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"21"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"24"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"22"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"55"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"3"}
PMC Usage Stats | Further Information
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"57", "full-text"=>"52", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"37", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"33", "full-text"=>"26", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"37", "full-text"=>"30", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"42", "full-text"=>"45", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"32", "full-text"=>"28", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"27", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"22", "full-text"=>"39", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"20", "full-text"=>"68", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"21", "full-text"=>"28", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
- {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
- {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
- {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
- {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
- {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
- {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
- {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
- {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
- {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
- {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
- {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
- {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
- {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
- {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
- {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
- {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
- {"unique-ip"=>"16", "full-text"=>"10", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
- {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
- {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
- {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
- {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
- {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
- {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
- {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
- {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
- {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
- {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
Relative Metric
{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

There are currently no alerts