The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA
- Publication Date
- April 29, 2016
- Journal
- PLOS Pathogens
- Authors
- Wan Li, Qin Yan, Xiangya Ding, Chenyou Shen, et al
- Volume
- 12
- Issue
- 4
- Pages
- e1005605
- DOI
- https://dx.plos.org/10.1371/journal.ppat.1005605
- Publisher URL
- http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005605
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/27128969
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851422
- Europe PMC
- http://europepmc.org/abstract/MED/27128969
- Web of Science
- 000378156900067
- Scopus
- 84964884515
- Mendeley
- http://www.mendeley.com/research/sh3bgrstat3-pathway-regulates-cell-migration-angiogenesis-induced-gammaherpesvirus-microrna
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Mendeley | Further Information
{"title"=>"The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA", "type"=>"journal", "authors"=>[{"first_name"=>"Wan", "last_name"=>"Li", "scopus_author_id"=>"55521331200"}, {"first_name"=>"Qin", "last_name"=>"Yan", "scopus_author_id"=>"55808071589"}, {"first_name"=>"Xiangya", "last_name"=>"Ding", "scopus_author_id"=>"57189035068"}, {"first_name"=>"Chenyou", "last_name"=>"Shen", "scopus_author_id"=>"56096512300"}, {"first_name"=>"Minmin", "last_name"=>"Hu", "scopus_author_id"=>"56999160100"}, {"first_name"=>"Ying", "last_name"=>"Zhu", "scopus_author_id"=>"56349151400"}, {"first_name"=>"Di", "last_name"=>"Qin", "scopus_author_id"=>"8771702100"}, {"first_name"=>"Hongmei", "last_name"=>"Lu", "scopus_author_id"=>"57188949030"}, {"first_name"=>"Brian J.", "last_name"=>"Krueger", "scopus_author_id"=>"56257390500"}, {"first_name"=>"Rolf", "last_name"=>"Renne", "scopus_author_id"=>"7003589017"}, {"first_name"=>"Shou Jiang", "last_name"=>"Gao", "scopus_author_id"=>"7403257411"}, {"first_name"=>"Chun", "last_name"=>"Lu", "scopus_author_id"=>"55733530800"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"scopus"=>"2-s2.0-84964884515", "issn"=>"15537374", "pmid"=>"27128969", "sgr"=>"84964884515", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)", "doi"=>"10.1371/journal.ppat.1005605", "pui"=>"610216765"}, "id"=>"9ff45a10-fa9c-3911-a364-0817f583b207", "abstract"=>"Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a gammaherpesvirus etiologically associated with KS, a highly disseminated angiogenic tumor of hyperproliferative spindle endothelial cells. KSHV encodes 25 mature microRNAs but their roles in KSHV-induced tumor dissemination and angiogenesis remain unknown. Here, we investigated KSHV-encoded miR-K12-6-3p (miR-K6-3p) promotion of endothelial cell migration and angiogenesis, which are the underlying mechanisms of tumor dissemination and angiogenesis. We found that ectopic expression of miR-K6-3p promoted endothelial cell migration and angiogenesis. Mass spectrometry, bioinformatics and luciferase reporter analyses revealed that miR-K6-3p directly targeted sequence in the 3' untranslated region (UTR) of SH3 domain binding glutamate-rich protein (SH3BGR). Overexpression of SH3BGR reversed miR-K6-3p induction of cell migration and angiogenesis. Mechanistically, miR-K6-3p downregulated SH3BGR, hence relieved STAT3 from SH3BGR direct binding and inhibition, which was required for miR-K6-3p maximum activation of STAT3 and induction of cell migration and angiogenesis. Finally, deletion of miR-K6 from the KSHV genome abrogated its effect on the SH3BGR/STAT3 pathway, and KSHV-induced migration and angiogenesis. Our results illustrated that, by inhibiting SH3BGR, miR-K6-3p enhances cell migration and angiogenesis by activating the STAT3 pathway, and thus contributes to the dissemination and angiogenesis of KSHV-induced malignancies.", "link"=>"http://www.mendeley.com/research/sh3bgrstat3-pathway-regulates-cell-migration-angiogenesis-induced-gammaherpesvirus-microrna", "reader_count"=>7, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}CrossRef
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Scopus | Further Information
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Relative Metric
{"start_date"=>"2016-01-01T00:00:00Z", "end_date"=>"2016-12-31T00:00:00Z", "subject_areas"=>[]}Loading … 

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