Vectors as Epidemiological Sentinels: Patterns of Within-Tick Borrelia burgdorferi Diversity
Publication Date
July 14, 2016
Journal
PLOS Pathogens
Authors
Katharine S. Walter, Giovanna Carpi, Benjamin R. Evans, Adalgisa Caccone, et al
Volume
12
Issue
7
Pages
e1005759
DOI
https://dx.plos.org/10.1371/journal.ppat.1005759
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005759
Web of Science
000383366400039
Scopus
84980561712
Mendeley
http://www.mendeley.com/research/vectors-epidemiological-sentinels-patterns-withintick-borrelia-burgdorferi-diversity
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Mendeley | Further Information

{"title"=>"Vectors as Epidemiological Sentinels: Patterns of Within-Tick Borrelia burgdorferi Diversity", "type"=>"journal", "authors"=>[{"first_name"=>"Katharine S.", "last_name"=>"Walter", "scopus_author_id"=>"56150056900"}, {"first_name"=>"Giovanna", "last_name"=>"Carpi", "scopus_author_id"=>"24832623100"}, {"first_name"=>"Benjamin R.", "last_name"=>"Evans", "scopus_author_id"=>"55893254100"}, {"first_name"=>"Adalgisa", "last_name"=>"Caccone", "scopus_author_id"=>"7003512116"}, {"first_name"=>"Maria A.", "last_name"=>"Diuk-Wasser", "scopus_author_id"=>"6507866842"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "pui"=>"611582093", "doi"=>"10.1371/journal.ppat.1005759", "sgr"=>"84983002181", "pmid"=>"27414806", "scopus"=>"2-s2.0-84983002181"}, "id"=>"84d200d7-72cd-307c-b755-55a7cbffff9e", "abstract"=>"Hosts including humans, other vertebrates, and arthropods, are frequently infected with heterogeneous populations of pathogens. Within-host pathogen diversity has major implications for human health, epidemiology, and pathogen evolution. However, pathogen diversity within-hosts is difficult to characterize and little is known about the levels and sources of within-host diversity maintained in natural populations of disease vectors. Here, we examine genomic variation of the Lyme disease bacteria, Borrelia burgdorferi (Bb), in 98 individual field-collected tick vectors as a model for study of within-host processes. Deep population sequencing reveals extensive and previously undocumented levels of Bb variation: the majority (~70%) of ticks harbor mixed strain infections, which we define as levels Bb diversity pre-existing in a diverse inoculum. Within-tick diversity is thus a sample of the variation present within vertebrate hosts. Within individual ticks, we detect signatures of positive selection. Genes most commonly under positive selection across ticks include those involved in dissemination in vertebrate hosts and evasion of the vertebrate immune complement. By focusing on tick-borne Bb, we show that vectors can serve as epidemiological and evolutionary sentinels: within-vector pathogen diversity can be a useful and unbiased way to survey circulating pathogen diversity and identify evolutionary processes occurring in natural transmission cycles.", "link"=>"http://www.mendeley.com/research/vectors-epidemiological-sentinels-patterns-withintick-borrelia-burgdorferi-diversity", "reader_count"=>33, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>2, "Philosophy"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>4}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Hungary"=>1, "United States"=>1, "United Kingdom"=>1, "France"=>1}, "group_count"=>0}

Scopus | Further Information

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