CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
Publication Date
July 14, 2016
Journal
PLOS Pathogens
Authors
Rémi Fromentin, Wendy Bakeman, Mariam B. Lawani, Gabriela Khoury, et al
Volume
12
Issue
7
Pages
e1005761
DOI
https://dx.plos.org/10.1371/journal.ppat.1005761
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005761
Web of Science
000383366400041
Scopus
84980495927
Mendeley
http://www.mendeley.com/research/cd4t-cells-expressing-pd1-tigit-lag3-contribute-hiv-persistence-during-art
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Mendeley | Further Information

{"title"=>"CD4+T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART", "type"=>"journal", "authors"=>[{"first_name"=>"Rémi", "last_name"=>"Fromentin", "scopus_author_id"=>"16432533700"}, {"first_name"=>"Wendy", "last_name"=>"Bakeman", "scopus_author_id"=>"55548070200"}, {"first_name"=>"Mariam B.", "last_name"=>"Lawani", "scopus_author_id"=>"55629451600"}, {"first_name"=>"Gabriela", "last_name"=>"Khoury", "scopus_author_id"=>"57190009846"}, {"first_name"=>"Wendy", "last_name"=>"Hartogensis", "scopus_author_id"=>"6506480718"}, {"first_name"=>"Sandrina", "last_name"=>"DaFonseca", "scopus_author_id"=>"23388423800"}, {"first_name"=>"Marisela", "last_name"=>"Killian", "scopus_author_id"=>"57196445020"}, {"first_name"=>"Lorrie", "last_name"=>"Epling", "scopus_author_id"=>"6504004984"}, {"first_name"=>"Rebecca", "last_name"=>"Hoh", "scopus_author_id"=>"7004664877"}, {"first_name"=>"Elizabeth", "last_name"=>"Sinclair", "scopus_author_id"=>"7006061259"}, {"first_name"=>"Frederick M.", "last_name"=>"Hecht", "scopus_author_id"=>"7103064306"}, {"first_name"=>"Peter", "last_name"=>"Bacchetti", "scopus_author_id"=>"7004977420"}, {"first_name"=>"Steven G.", "last_name"=>"Deeks", "scopus_author_id"=>"7006700221"}, {"first_name"=>"Sharon R.", "last_name"=>"Lewin", "scopus_author_id"=>"15737239300"}, {"first_name"=>"Rafick Pierre", "last_name"=>"Sékaly", "scopus_author_id"=>"7103324485"}, {"first_name"=>"Nicolas", "last_name"=>"Chomont", "scopus_author_id"=>"6506871784"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"pmid"=>"27415008", "issn"=>"15537374", "doi"=>"10.1371/journal.ppat.1005761", "pui"=>"611582094", "isbn"=>"1553-7366", "scopus"=>"2-s2.0-84982993334", "sgr"=>"84982993334"}, "id"=>"b22eec85-71df-38e4-8adc-59d7a2fcf300", "abstract"=>"HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hypothesized that CD4+ T cells expressing immune checkpoint molecules would be enriched in HIV-infected cells in individuals receiving suppressive ART. Expression levels of 7 immune checkpoint molecules (PD-1, CTLA-4, LAG-3, TIGIT, TIM-3, CD160 and 2B4) as well as 4 markers of HIV persistence (integrated and total HIV DNA, 2-LTR circles and cell-associated unspliced HIV RNA) were measured in PBMCs from 48 virally suppressed individuals. Using negative binomial regression models, we identified PD-1, TIGIT and LAG-3 as immune checkpoint molecules positively associated with the frequency of CD4+ T cells harboring integrated HIV DNA. The frequency of CD4+ T cells co-expressing PD-1, TIGIT and LAG-3 independently predicted the frequency of cells harboring integrated HIV DNA. Quantification of HIV genomes in highly purified cell subsets from blood further revealed that expressions of PD-1, TIGIT and LAG-3 were associated with HIV-infected cells in distinct memory CD4+ T cell subsets. CD4+ T cells co-expressing the three markers were highly enriched for integrated viral genomes (median of 8.2 fold compared to total CD4+ T cells). Importantly, most cells carrying inducible HIV genomes expressed at least one of these markers (median contribution of cells expressing LAG-3, PD-1 or TIGIT to the inducible reservoir = 76%). Our data provide evidence that CD4+ T cells expressing PD-1, TIGIT and LAG-3 alone or in combination are enriched for persistent HIV during ART and suggest that immune checkpoint blockers directed against these receptors may represent valuable tools to target latently infected cells in virally suppressed individuals.", "link"=>"http://www.mendeley.com/research/cd4t-cells-expressing-pd1-tigit-lag3-contribute-hiv-persistence-during-art", "reader_count"=>75, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>7, "Researcher"=>22, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>7, "Researcher"=>22, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>11, "Medicine and Dentistry"=>19, "Agricultural and Biological Sciences"=>22, "Veterinary Science and Veterinary Medicine"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>17}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>17}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>11}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Denmark"=>1, "Germany"=>1}, "group_count"=>4}

CrossRef

Scopus | Further Information

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