Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A
Publication Date
September 22, 2016
Journal
PLOS Pathogens
Authors
Mary Anne Hartley, Eliane Bourreau, Matteo Rossi, Patrik Castiglioni, et al
Volume
12
Issue
9
Pages
e1005852
DOI
https://dx.plos.org/10.1371/journal.ppat.1005852
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1005852
Web of Science
000385621900024
Scopus
84989812003
Mendeley
http://www.mendeley.com/research/leishmaniavirusdependent-metastatic-leishmaniasis-prevented-blocking-il17a
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Mendeley | Further Information

{"title"=>"Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A", "type"=>"journal", "authors"=>[{"first_name"=>"Mary Anne", "last_name"=>"Hartley", "scopus_author_id"=>"55243297200"}, {"first_name"=>"Eliane", "last_name"=>"Bourreau", "scopus_author_id"=>"6602116978"}, {"first_name"=>"Matteo", "last_name"=>"Rossi", "scopus_author_id"=>"57191407860"}, {"first_name"=>"Patrik", "last_name"=>"Castiglioni", "scopus_author_id"=>"55583729400"}, {"first_name"=>"Remzi Onur", "last_name"=>"Eren", "scopus_author_id"=>"56154982300"}, {"first_name"=>"Florence", "last_name"=>"Prevel", "scopus_author_id"=>"38762038000"}, {"first_name"=>"Pierre", "last_name"=>"Couppié", "scopus_author_id"=>"7006805452"}, {"first_name"=>"Suzanne M.", "last_name"=>"Hickerson", "scopus_author_id"=>"6602524621"}, {"first_name"=>"Pascal", "last_name"=>"Launois", "scopus_author_id"=>"7004874259"}, {"first_name"=>"Stephen M.", "last_name"=>"Beverley", "scopus_author_id"=>"7004527986"}, {"first_name"=>"Catherine", "last_name"=>"Ronet", "scopus_author_id"=>"6602885783"}, {"first_name"=>"Nicolas", "last_name"=>"Fasel", "scopus_author_id"=>"7004421554"}], "year"=>2016, "source"=>"PLoS Pathogens", "identifiers"=>{"pui"=>"612522303", "sgr"=>"84989812003", "issn"=>"15537374", "pmid"=>"27658195", "scopus"=>"2-s2.0-84989812003", "doi"=>"10.1371/journal.ppat.1005852", "isbn"=>"1553-7374 (Electronic)\\r1553-7366 (Linking)"}, "id"=>"185a2914-ef58-3459-89a6-4ba474e2b2b3", "abstract"=>"© 2016 Hartley et al.Cutaneous leishmaniasis has various outcomes, ranging from self-healing reddened papules to extensive open ulcerations that metastasise to secondary sites and are often resistant to standard therapies. In the case of L. guyanensis (L.g), about 5–10% of all infections result in metastatic complications. We recently showed that a cytoplasmic virus within L.g parasites (LRV1) is able to act as a potent innate immunogen, worsening disease outcome in a murine model. In this study, we investigated the immunophenotype of human patients infected by L.g and found a significant association between the inflammatory cytokine IL-17A, the presence of LRV1 and disease chronicity. Further, IL-17A was inversely correlated to the protective cytokine IFN-γ. These findings were experimentally corroborated in our murine model, where IL-17A produced in LRV1+ L.g infection contributed to parasite virulence and dissemination in the absence of IFN-γ. Additionally, IL-17A inhibition in mice using digoxin or SR1001, showed therapeutic promise in limiting parasite virulence. Thus, this murine model of LRV1-dependent infectious metastasis validated markers of disease chronicity in humans and elucidated the immunologic mechanism for the dissemination of Leishmania parasites to secondary sites. Moreover, it confirms the prognostic value of LRV1 and IL-17A detection to prevent metastatic leishmaniasis in human patients.", "link"=>"http://www.mendeley.com/research/leishmaniavirusdependent-metastatic-leishmaniasis-prevented-blocking-il17a", "reader_count"=>26, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>3, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>3, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>3, "Veterinary Science and Veterinary Medicine"=>3, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>0}

Scopus | Further Information

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