Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission
Publication Date
February 15, 2018
Authors
Yogy Simanjuntak, Jian Jong Liang, Si Yu Chen, Jin Kun Li, et al
Volume
14
Issue
2
Pages
e1006854
DOI
https://dx.plos.org/10.1371/journal.ppat.1006854
Publisher URL
http://journals.plos.org/plospathogens/article?id=10.1371%2Fjournal.ppat.1006854
Scopus
85042684293
Mendeley
http://www.mendeley.com/research/ebselen-alleviates-testicular-pathology-mice-zika-virus-infection-prevents-sexual-transmission
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission", "type"=>"journal", "authors"=>[{"first_name"=>"Yogy", "last_name"=>"Simanjuntak", "scopus_author_id"=>"56512250300"}, {"first_name"=>"Jian Jong", "last_name"=>"Liang", "scopus_author_id"=>"35205755100"}, {"first_name"=>"Si Yu", "last_name"=>"Chen", "scopus_author_id"=>"57200968553"}, {"first_name"=>"Jin Kun", "last_name"=>"Li", "scopus_author_id"=>"53064000400"}, {"first_name"=>"Yi Ling", "last_name"=>"Lee", "scopus_author_id"=>"57200961955"}, {"first_name"=>"Han Chung", "last_name"=>"Wu", "scopus_author_id"=>"57200960372"}, {"first_name"=>"Yi Ling", "last_name"=>"Lin", "scopus_author_id"=>"57200422811"}], "year"=>2018, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "doi"=>"10.1371/journal.ppat.1006854", "sgr"=>"85042684293", "scopus"=>"2-s2.0-85042684293", "isbn"=>"1111111111", "pmid"=>"29447264", "pui"=>"620981896"}, "id"=>"c86fa368-b857-3339-b4dc-9c0e6dc7f916", "abstract"=>"Despite the low case fatality, Zika virus (ZIKV) infection has been associated with micro-cephaly in infants and Guillain-Barré syndrome. Antiviral and vaccine developments against ZIKV are still ongoing; therefore, in the meantime, preventing the disease trans-mission is critical. Primarily transmitted by Aedes species mosquitoes, ZIKV also can be sexually transmitted. We used AG129 mice lacking interferon-α/β and -γ receptors to study the testicular pathogenesis and sexual transmission of ZIKV. Infection of ZIKV pro-gressively damaged mouse testes, increased testicular oxidative stress as indicated by the levels of reactive oxygen species, nitric oxide, glutathione peroxidase 4, spermatogen-esis-associated-18 homolog in sperm and pro-inflammatory cytokines including IL-1β, IL-6, and G-CSF. We then evaluated the potential role of the antioxidant ebselen (EBS) in alleviating the testicular pathology with ZIKV infection. EBS treatment significantly reduced ZIKV-induced testicular oxidative stress, leucocyte infiltration and production of pro-inflammatory response. Furthermore, it improved testicular pathology and prevented the sexual transmission of ZIKV in a male-to-female mouse sperm transfer model. EBS is currently in clinical trials for various diseases. ZIKV infection could be on the list for poten-tial use of EBS, for alleviating the testicular pathogenesis with ZIKV infection and prevent-ing its sexual transmission. Author summary", "link"=>"http://www.mendeley.com/research/ebselen-alleviates-testicular-pathology-mice-zika-virus-infection-prevents-sexual-transmission", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>5, "Lecturer"=>1, "Researcher"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>5, "Lecturer"=>1, "Researcher"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Business, Management and Accounting"=>1, "Immunology and Microbiology"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85042684293"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85042684293?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042684293&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85042684293&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85042684293", "dc:identifier"=>"SCOPUS_ID:85042684293", "eid"=>"2-s2.0-85042684293", "dc:title"=>"Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission", "dc:creator"=>"Simanjuntak Y.", "prism:publicationName"=>"PLoS Pathogens", "prism:issn"=>"15537366", "prism:eIssn"=>"15537374", "prism:volume"=>"14", "prism:issueIdentifier"=>"2", "prism:pageRange"=>nil, "prism:coverDate"=>"2018-02-01", "prism:coverDisplayDate"=>"February 2018", "prism:doi"=>"10.1371/journal.ppat.1006854", "citedby-count"=>"24", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Academia Sinica, Institute of Biomedical Sciences", "affiliation-city"=>"Taipei", "affiliation-country"=>"Taiwan"}], "pubmed-id"=>"29447264", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1006854", "source-id"=>"4000151809", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Counter

  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"379", "xml_views"=>"45", "html_views"=>"650"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"243", "xml_views"=>"28", "html_views"=>"301"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"92", "xml_views"=>"1", "html_views"=>"112"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"60", "xml_views"=>"4", "html_views"=>"75"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"44", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"2", "html_views"=>"66"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"51", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"41", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"28", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"72", "xml_views"=>"7", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"122", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"213", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"7"}
  • {"month"=>"1", "year"=>"2021", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2021", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}

PMC Usage Stats

  • {"unique-ip"=>"41", "full-text"=>"38", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"34", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"30", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"21", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"39", "full-text"=>"35", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"24", "full-text"=>"15", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"8", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"3", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"5", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}
Loading … Spinner
There are currently no alerts