Mendeley | Further Information

{"title"=>"Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission", "type"=>"journal", "authors"=>[{"first_name"=>"Yogy", "last_name"=>"Simanjuntak", "scopus_author_id"=>"56512250300"}, {"first_name"=>"Jian Jong", "last_name"=>"Liang", "scopus_author_id"=>"35205755100"}, {"first_name"=>"Si Yu", "last_name"=>"Chen", "scopus_author_id"=>"57200968553"}, {"first_name"=>"Jin Kun", "last_name"=>"Li", "scopus_author_id"=>"53064000400"}, {"first_name"=>"Yi Ling", "last_name"=>"Lee", "scopus_author_id"=>"57200961955"}, {"first_name"=>"Han Chung", "last_name"=>"Wu", "scopus_author_id"=>"57200960372"}, {"first_name"=>"Yi Ling", "last_name"=>"Lin", "scopus_author_id"=>"57200422811"}], "year"=>2018, "source"=>"PLoS Pathogens", "identifiers"=>{"issn"=>"15537374", "doi"=>"10.1371/journal.ppat.1006854", "sgr"=>"85042684293", "scopus"=>"2-s2.0-85042684293", "isbn"=>"1111111111", "pmid"=>"29447264", "pui"=>"620981896"}, "id"=>"c86fa368-b857-3339-b4dc-9c0e6dc7f916", "abstract"=>"Despite the low case fatality, Zika virus (ZIKV) infection has been associated with micro-cephaly in infants and Guillain-Barré syndrome. Antiviral and vaccine developments against ZIKV are still ongoing; therefore, in the meantime, preventing the disease trans-mission is critical. Primarily transmitted by Aedes species mosquitoes, ZIKV also can be sexually transmitted. We used AG129 mice lacking interferon-α/β and -γ receptors to study the testicular pathogenesis and sexual transmission of ZIKV. Infection of ZIKV pro-gressively damaged mouse testes, increased testicular oxidative stress as indicated by the levels of reactive oxygen species, nitric oxide, glutathione peroxidase 4, spermatogen-esis-associated-18 homolog in sperm and pro-inflammatory cytokines including IL-1β, IL-6, and G-CSF. We then evaluated the potential role of the antioxidant ebselen (EBS) in alleviating the testicular pathology with ZIKV infection. EBS treatment significantly reduced ZIKV-induced testicular oxidative stress, leucocyte infiltration and production of pro-inflammatory response. Furthermore, it improved testicular pathology and prevented the sexual transmission of ZIKV in a male-to-female mouse sperm transfer model. EBS is currently in clinical trials for various diseases. ZIKV infection could be on the list for poten-tial use of EBS, for alleviating the testicular pathogenesis with ZIKV infection and prevent-ing its sexual transmission. Author summary", "link"=>"http://www.mendeley.com/research/ebselen-alleviates-testicular-pathology-mice-zika-virus-infection-prevents-sexual-transmission", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>5, "Lecturer"=>1, "Researcher"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>5, "Lecturer"=>1, "Researcher"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Business, Management and Accounting"=>1, "Immunology and Microbiology"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Mathematics"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

CrossRef

• http://doi.org/10.1021/acsinfecdis.9b00526
• http://doi.org/10.1371/journal.ppat.1008521
• http://doi.org/10.1016/j.bjid.2020.09.001
• http://doi.org/10.1371/journal.pntd.0006691
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• http://doi.org/10.1016/j.ijsu.2020.10.018
• http://doi.org/10.4155/fmc-2019-0218
• http://doi.org/10.1038/s41598-019-51954-8
• http://doi.org/10.1146/annurev-virology-092818-015740
• http://doi.org/10.1371/journal.ppat.1009019
• http://doi.org/10.1371/journal.pmed.1002611
• http://doi.org/10.1016/j.mencom.2019.01.033
• http://doi.org/10.1021/acs.jmedchem.9b01779
• http://doi.org/10.3390/cells9041006
• http://doi.org/10.3390/v10090453
• http://doi.org/10.1080/13543784.2018.1548609
• http://doi.org/10.1371/journal.ppat.1008601
• http://doi.org/10.3389/fmicb.2019.02250
• http://doi.org/10.1038/s41467-018-07782-x
• http://doi.org/10.1093/hmg/ddz218
• http://doi.org/10.3390/v12090933
• http://doi.org/10.3390/ph12030127

Scopus | Further Information

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• {"id"=>"1015612503080996865", "text"=>"Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmiss... https://t.co/EPHyGpYpKF", "created_at"=>"2018-07-07T15:04:24Z", "user"=>"ISPM_ZOAP", "user_name"=>"Zika Open Access Project", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1007539129435983874/p2rWObJa_normal.jpg"}

Wikipedia | Further Information

• {"title"=>"Virus del Zika", "url"=>"http://ca.wikipedia.org/wiki/Virus_del_Zika", "timestamp"=>"2018-12-31T12:47:05Z"}

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